Patients with type 2 diabetes mellitus present similar immunological response to COVID-19 BNT162b2 mRNA vaccine to healthy subjects: a prospective cohort study

被引：5

作者：

Paschou, Stavroula A. ^{[1
]}

Karalis, Vangelis ^{[2
]}

Psaltopoulou, Theodora ^{[3
]}

Charitaki, Ioanna ^{[3
]}

Sklirou, Aimilia D. ^{[4
]}

Iconomidou, Vassiliki A. ^{[4
]}

Vasileiou, Vasiliki ^{[5
]}

Kassi, Georgia N. ^{[5
]}

Vryonidou, Andromachi ^{[6
,7
]}

Kokkinos, Alexander ^{[8
]}

Tentolouris, Nicholas ^{[8
]}

Hatziaggelaki, Erifili ^{[9
]}

Trougakos, Ioannis P. ^{[4
]}

Terpos, Evangelos ^{[3
]}

Dimopoulos, Meletios Athanasios ^{[3
]}

机构：

[1] Natl & Kapodistrian Univ Athens, Sch Med, Alexandra Hosp, Endocrine Unit & Diabet Ctr,Dept Clin Therapeut, Athens, Greece

[2] Natl & Kapodistrian Univ Athens, Sch Hlth Sci, Fac Pharm, Athens, Greece

[3] Natl & Kapodistrian Univ Athens, Sch Med, Alexandra Hosp, Dept Clin Therapeut, 80 Vasilisis Sophias Ave, Athens 11528, Greece

[4] Natl & Kapodistrian Univ Athens, Fac Biol, Dept Cell Biol & Biophys, Athens, Greece

[5] Alexandra Hosp, Dept Endocrinol, Athens, Greece

[6] Hellen Red Cross Hosp, Dept Endocrinol, Athens, Greece

[7] Hellen Red Cross Hosp, Diabet Ctr, Athens, Greece

[8] Natl & Kapodistrian Univ Athens, Laiko Gen Hosp, Dept Propaedeut Internal Med 1, Diabet Ctr, Athens, Greece

[9] Natl & Kapodistrian Univ Athens, Attikon Univ Hosp, Dept Internal Med 2, Diabet Ctr, Athens, Greece

来源：

HORMONES-INTERNATIONAL JOURNAL OF ENDOCRINOLOGY AND METABOLISM | 2023年 / 22卷 / 01期

关键词：

Type; 2; diabetes; Diabetes mellitus; Hyperglycemia; Vaccination; COVID-19; Immune response; SARS-CoV-2; ENDOCRINE;

D O I：

10.1007/s42000-022-00405-7

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Aim To compare the kinetics of neutralizing antibodies (N Alpha bs) against SARS-CoV-2 after vaccination with the BNT162b2 mRNA vaccine (Comirnaty, Pfizer/BioNTech) between patients with T2DM and healthy controls. Methods NAb levels after the BNT162b2 mRNA vaccine were compared between 50 patients with non-insulin treated T2DM and 50 age-, gender-, and BMI-matched healthy controls up to 3 months after the second dose. The median age of both groups was 70 years. Results On day 1, mean NAbs of the control and T2DM groups were 14.64% (standard error, SE = 2.30) and 14.04% (SE = 2.14), respectively (p value = 0.926). Three weeks later, the mean NAb values were 39.98% (SE = 3.53) in the control group and 40.97% (SE = 3.99) in participants with T2DM (p value = 0.698). One month after the second vaccination, mean NAb values increased to 87.13% (SE = 2.94) in the control group and 89.00% (SE = 2.18) in the T2DM group. Three months after the second vaccine dose, the mean inhibitory titers decreased to 83.49% (SE = 3.82) (control group) and 76.36% (SE = 3.33) (T2DM group). On all occasions, no significant difference was found between the two groups (all p values > 0.05). Conclusions Patients with T2DM present similar immunological response to COVID-19 BNT162b2 mRNA vaccine to that of healthy subjects.

引用

页码：5 / 11

页数：7

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