Mechanisms of Cytokine-Induced NK Cell Therapy: IL-12/15/18 Induce a Unique Transcriptional, Epigenetic, and Functional Human NK Cell Memory Program

被引:1
|
作者
Tran, Jennifer [1 ]
Foltz, Jennifer Ann [1 ]
Wong, Pamela [1 ]
Fan, Changxu [1 ]
Becker-Hapak, Michelle [1 ]
Marin, Nancy D. [1 ]
Cubitt, Celia C. [1 ]
Russler-Germain, David A. [1 ]
Foster, Mark [1 ]
Schappe, Timothy [1 ]
Marsala, Lynne [1 ]
Rueve, Joseph [1 ]
Hwang, Kimberly [1 ]
Wang, Ting [1 ]
Berrien-Elliott, Melissa M. [1 ]
Cashen, Amanda F. [1 ]
Bednarski, Jeffrey J. [1 ]
Griffith, Obi [1 ]
Griffith, Malachi [1 ]
Petti, Allegra [2 ]
Fehniger, Todd A. [1 ]
机构
[1] Washington Univ, Sch Med, St Louis, MO USA
[2] Massachusetts Gen Hosp, Boston, MA USA
关键词
D O I
10.1182/blood-2023-182435
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
703
引用
收藏
页数:3
相关论文
共 50 条
  • [1] IL-12/15/18-induced cell death and mitochondrial dynamics of human NK cells
    Terren, Inigo
    Sanda, Victor
    Amarilla-Irusta, Ainhoa
    Lopez-Pardo, Ainara
    Sevilla, Arrate
    Astarloa-Pando, Gabirel
    Amo, Laura
    Zenarruzabeitia, Olatz
    Scorrano, Luca
    Borrego, Francisco
    FRONTIERS IN IMMUNOLOGY, 2023, 14
  • [2] Combined IL-12, IL-15 and IL-18 activation induces epigenetic changes in human NK cells during the memory-like state transition
    Tran, Jennifer
    Wong, Pamela
    Fan, Changxu
    Russler-Germain, David
    Cubitt, Celia C.
    Marin, Nancy D.
    Schappe, Timothy
    Berrien-Elliott, Melissa
    Wang, Ting
    Foltz, Jennifer A.
    Fehniger, Todd A.
    JOURNAL OF IMMUNOLOGY, 2023, 210 (01):
  • [3] Brief IL-12, IL-15, IL-18 activation drives the acquisition of two distinct memory-like NK cell states
    Foltz, Jennifer Ann
    Tran, Jennifer
    Fisk, Bryan
    Wong, Pamela
    Khan, Saad M.
    Berrien-Elliott, Melissa M.
    Becker-Hapak, Michelle
    Russler-Germain, David A.
    Marsala, Lynne
    Bednarski, Jeffrey J.
    Zimmerman, Clare
    Cubitt, Celia C.
    Marin, Nancy D.
    Zhou, Alice Y.
    Jacobs, Miriam T.
    Foster, Mark
    Schappe, Timothy
    Pence, Patrick
    Cashen, Amanda
    Griffith, Obi L.
    Griffith, Malachi
    Petti, Allegra A.
    Fehniger, Todd A.
    JOURNAL OF IMMUNOLOGY, 2023, 210 (01):
  • [4] The combined action of IL-15 and IL-12 gene transfer can induce tumor cell rejection without T and NK cell involvement
    Di Carlo, E
    Comes, A
    Basso, S
    De Ambrosis, A
    Meazza, R
    Musiani, P
    Moelling, K
    Albini, A
    Ferrini, S
    JOURNAL OF IMMUNOLOGY, 2000, 165 (06): : 3111 - 3118
  • [5] Cytokine production and killer activity of NK/T-NK cells derived with IL-2, IL-15, or the combination of IL-12 and IL-18
    Lauwerys, BR
    Garot, N
    Renauld, JC
    Houssiau, FA
    JOURNAL OF IMMUNOLOGY, 2000, 165 (04): : 1847 - 1853
  • [6] Generation of NK cell memory requires IL-12 and STAT4 signaling
    Madera, Sharline
    Sun, Joseph
    JOURNAL OF IMMUNOLOGY, 2012, 188
  • [7] Comparison in the effects of IL-2, IL-12, IL-15 and IFNα on gene regulation of granzymes of human NK cell line NK-92
    Zhang, Bin
    Zhang, Jian
    Tian, Zhigang
    INTERNATIONAL IMMUNOPHARMACOLOGY, 2008, 8 (07) : 989 - 996
  • [8] TL1A Selectively Enhances IL-12/IL-18-Induced NK Cell Cytotoxicity against NK-Resistant Tumor Targets
    Stephanie C. Heidemann
    Valerie Chavez
    Carol J. Landers
    Torsten Kucharzik
    John L. Prehn
    Stephan R. Targan
    Journal of Clinical Immunology, 2010, 30 : 531 - 538
  • [9] TL1A Selectively Enhances IL-12/IL-18-Induced NK Cell Cytotoxicity against NK-Resistant Tumor Targets
    Heidemann, Stephanie C.
    Chavez, Valerie
    Landers, Carol J.
    Kucharzik, Torsten
    Prehn, John L.
    Targan, Stephan R.
    JOURNAL OF CLINICAL IMMUNOLOGY, 2010, 30 (04) : 531 - 538
  • [10] Combined Cytokine therapy IL-12 plus IL-15 enhance NK cell function both in vitro and in vivo during chronic SIV infection
    Babu, Hemalatha
    Govindaraj, Sakthivel
    Rahman, Sheikh Abdul
    Wagoner, Isabelle
    Ibegbu, Chris
    Villinger, Francois
    Amara, Rama
    Velu, Vijayakumar
    JOURNAL OF MEDICAL PRIMATOLOGY, 2022, 51 (05) : 324 - 324