The Molecular Biology of Midgut Neuroendocrine Neoplasms

被引：5

作者：

Webster, Amy P. ^{[1
,3
]}

Thirlwell, Chrissie ^{[1
,2
]}

机构：

[1] Univ Exeter, Dept Clin & Biomed Sci, Coll Med & Hlth, Exeter EX2 5DW, England

[2] Univ Bristol, Med Sch, Bristol BS8 1UD, England

[3] Univ Exeter, Med Sch, St Lukes Campus,Heavitree Rd, Exeter EX1 2LU, England

来源：

ENDOCRINE REVIEWS | 2024年 / 45卷 / 03期

关键词：

neuroendocrine neoplasms; neuroendocrine tumors; genetics; epigenetics; DNA methylation; molecular biology; POPULATION-BASED ANALYSIS; CARCINOID-TUMORS; GERMLINE MUTATION; DNA METHYLATION; EPIDEMIOLOGY; MANAGEMENT; MULTIFOCALITY; DIAGNOSIS; BIOMARKER; ORIGIN;

D O I：

10.1210/endrev/bnad034

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Midgut neuroendocrine neoplasms (NENs) are one of the most common subtypes of NEN, and their incidence is rising globally. Despite being the most frequently diagnosed malignancy of the small intestine, little is known about their underlying molecular biology. Their unusually low mutational burden compared to other solid tumors and the unexplained occurrence of multifocal tumors makes the molecular biology of midgut NENs a particularly fascinating field of research. This review provides an overview of recent advances in the understanding of the interplay of the genetic, epigenetic, and transcriptomic landscape in the development of midgut NENs, a topic that is critical to understanding their biology and improving treatment options and outcomes for patients. Graphical Abstract

引用

页码：343 / 350

页数：8

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