The role of gut microbiota in human metabolism and inflammatory diseases: a focus on elderly individuals

被引：12
作者：
Khaledi, Mansoor [1 ,2 ]
Poureslamfar, Behnam [3 ]
Alsaab, Hashem O. [4 ]
Tafaghodi, Shahrad [5 ]
Hjazi, Ahmed [6 ]
Singh, Rajesh [7 ]
Alawadi, Ahmed Hussien [8 ]
Alsaalamy, Ali [9 ]
Qasim, Qutaiba A. [10 ]
Sameni, Fatemeh [1 ]
机构：
[1] Shahed Univ, Fac Med, Dept Microbiol, Tehran, Iran
[2] Shahrekord Univ Med Sci, Sch Med, Dept Microbiol & Immunol, Shahrekord, Iran
[3] Univ Yasuj, Fac Sci, Dept Biol, Yasuj, Iran
[4] Taif Univ, Dept Pharmaceut & Pharmaceut Technol, Taif 21944, Saudi Arabia
[5] Isfahan Univ Med Sci, Dept Clin Biochem, Sch Pharm & Pharmaceut Sci, Esfahan, Iran
[6] Prince Sattam Bin Abdulaziz Univ, Coll Appl Med Sci, Dept Med Lab Sci, Al Kharj 11942, Saudi Arabia
[7] Uttaranchal Univ, Uttaranchal Inst Technol, Dept Elect & Commun Engn, Dehra Dun 248007, India
[8] Islamic Univ, Coll Tech Engn, Najaf, Iraq
[9] Imam Jaafar Al Sadiq Univ, Coll Tech Engn, Al Muthanna 66002, Iraq
[10] Al Ayen Univ, Coll Pharm, Thi Qar, Iraq
来源：
ANNALS OF MICROBIOLOGY | 2024年 / 74卷 / 01期
关键词：
Gut microbiota; Aging; Inflammatory disease; Metabolism; Probiotic; CLOSTRIDIUM-DIFFICILE INFECTION; MITOCHONDRIAL-DNA MUTATIONS; INVASIVE ESCHERICHIA-COLI; SULFATE-REDUCING BACTERIA; CHAIN FATTY-ACIDS; INTESTINAL MICROBIOTA; FECAL MICROBIOTA; MOUSE MODEL; MINERAL METABOLISM; GLUCOSE-METABOLISM;
D O I：
10.1186/s13213-023-01744-5
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
BackgroundThe gut microbiota plays a crucial role in regulating the host's immune responses during aging, which was characterized by a different abundance of bacteria in several age groups.Main bodyGut microbiota dysbiosis is associated with aging, antibiotic exposure, underlying diseases, infections, hormonal variations, circadian rhythm, and malnutrition, either singularly or in combination. The appropriate use of prebiotics and probiotics may be able to prevent or reduce this disruption.ConclusionThe current review focuses on the gut microbiota composition across the life cycle, factors affecting gut microbiota changes with aging, and interventions to modulate gut microbiota.
引用
收藏
页数：24
相关论文
共 288 条
  • [41] Gut microbiota composition correlates with diet and health in the elderly
    Claesson, Marcus J.
    Jeffery, Ian B.
    Conde, Susana
    Power, Susan E.
    O'Connor, Eibhlis M.
    Cusack, Siobhan
    Harris, Hugh M. B.
    Coakley, Mairead
    Lakshminarayanan, Bhuvaneswari
    O'Sullivan, Orla
    Fitzgerald, Gerald F.
    Deane, Jennifer
    O'Connor, Michael
    Harnedy, Norma
    O'Connor, Kieran
    O'Mahony, Denis
    van Sinderen, Douwe
    Wallace, Martina
    Brennan, Lorraine
    Stanton, Catherine
    Marchesi, Julian R.
    Fitzgerald, Anthony P.
    Shanahan, Fergus
    Hill, Colin
    Ross, R. Paul
    O'Toole, Paul W.
    [J]. NATURE, 2012, 488 (7410) : 178 - +
  • [42] Minireview: Gut Microbiota: The Neglected Endocrine Organ
    Clarke, Gerard
    Stilling, Roman M.
    Kennedy, Paul J.
    Stanton, Catherine
    Cryan, John F.
    Dinan, Timothy G.
    [J]. MOLECULAR ENDOCRINOLOGY, 2014, 28 (08) : 1221 - 1238
  • [43] Exercise and associated dietary extremes impact on gut microbial diversity
    Clarke, Siobhan F.
    Murphy, Eileen F.
    O'Sullivan, Orla
    Lucey, Alice J.
    Humphreys, Margaret
    Hogan, Aileen
    Hayes, Paula
    O'Reilly, Maeve
    Jeffery, Ian B.
    Wood-Martin, Ruth
    Kerins, David M.
    Quigley, Eamonn
    Ross, R. Paul
    O'Toole, Paul W.
    Molloy, Michael G.
    Falvey, Eanna
    Shanahan, Fergus
    Cotter, Paul D.
    [J]. GUT, 2014, 63 (12) : 1913 - 1920
  • [44] Frailty in elderly people
    Clegg, Andrew
    Young, John
    Iliffe, Steve
    Rikkert, Marcel Olde
    Rockwood, Kenneth
    [J]. LANCET, 2013, 381 (9868) : 752 - 762
  • [45] The Impact of the Gut Microbiota on Human Health: An Integrative View
    Clemente, Jose C.
    Ursell, Luke K.
    Parfrey, Laura Wegener
    Knight, Rob
    [J]. CELL, 2012, 148 (06) : 1258 - 1270
  • [46] Gut microbiota and old age: Modulating factors and interventions for healthy longevity
    Coman, Vasile
    Vodnar, Dan Cristian
    [J]. EXPERIMENTAL GERONTOLOGY, 2020, 141
  • [47] Gut Microbiome Developmental Patterns in Early Life of Preterm Infants: Impacts of Feeding and Gender
    Cong, Xiaomei
    Xu, Wanli
    Janton, Susan
    Henderson, Wendy A.
    Matson, Adam
    McGrath, Jacqueline M.
    Maas, Kendra
    Graf, Joerg
    [J]. PLOS ONE, 2016, 11 (04):
  • [48] Origins and evolution of the Western diet: health implications for the 21st century
    Cordain, L
    Eaton, SB
    Sebastian, A
    Mann, N
    Lindeberg, S
    Watkins, BA
    O'Keefe, JH
    Brand-Miller, J
    [J]. AMERICAN JOURNAL OF CLINICAL NUTRITION, 2005, 81 (02) : 341 - 354
  • [49] Bacteriocin production as a mechanism for the antfinfective activity of Lactobacillus salivarius UCC118
    Corr, Sinead C.
    Li, Yin
    Riedel, Christian U.
    O'Toole, Paul W.
    Hill, Colin
    Gahan, Cormac G. M.
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2007, 104 (18) : 7617 - 7621
  • [50] Effects of Soluble Corn Fiber Alone or in Synbiotic Combination with Lactobacillus rhamnosus GG and the Pilus-Deficient Derivative GG-PB12 on Fecal Microbiota, Metabolism, and Markers of immune Function: A Randomized, Double-Blind, Placebo-Controlled, Crossover Study in Healthy Elderly (Saimes Study)
    Costabile, Adele
    Bergillos-Meca, Triana
    Rasinkangas, Pia
    Korpela, Katri
    de Vos, Willem M.
    Gibson, Glenn R.
    [J]. FRONTIERS IN IMMUNOLOGY, 2017, 8
12345678910