The role of gut microbiota in human metabolism and inflammatory diseases: a focus on elderly individuals

被引：12
作者：
Khaledi, Mansoor [1 ,2 ]
Poureslamfar, Behnam [3 ]
Alsaab, Hashem O. [4 ]
Tafaghodi, Shahrad [5 ]
Hjazi, Ahmed [6 ]
Singh, Rajesh [7 ]
Alawadi, Ahmed Hussien [8 ]
Alsaalamy, Ali [9 ]
Qasim, Qutaiba A. [10 ]
Sameni, Fatemeh [1 ]
机构：
[1] Shahed Univ, Fac Med, Dept Microbiol, Tehran, Iran
[2] Shahrekord Univ Med Sci, Sch Med, Dept Microbiol & Immunol, Shahrekord, Iran
[3] Univ Yasuj, Fac Sci, Dept Biol, Yasuj, Iran
[4] Taif Univ, Dept Pharmaceut & Pharmaceut Technol, Taif 21944, Saudi Arabia
[5] Isfahan Univ Med Sci, Dept Clin Biochem, Sch Pharm & Pharmaceut Sci, Esfahan, Iran
[6] Prince Sattam Bin Abdulaziz Univ, Coll Appl Med Sci, Dept Med Lab Sci, Al Kharj 11942, Saudi Arabia
[7] Uttaranchal Univ, Uttaranchal Inst Technol, Dept Elect & Commun Engn, Dehra Dun 248007, India
[8] Islamic Univ, Coll Tech Engn, Najaf, Iraq
[9] Imam Jaafar Al Sadiq Univ, Coll Tech Engn, Al Muthanna 66002, Iraq
[10] Al Ayen Univ, Coll Pharm, Thi Qar, Iraq
来源：
ANNALS OF MICROBIOLOGY | 2024年 / 74卷 / 01期
关键词：
Gut microbiota; Aging; Inflammatory disease; Metabolism; Probiotic; CLOSTRIDIUM-DIFFICILE INFECTION; MITOCHONDRIAL-DNA MUTATIONS; INVASIVE ESCHERICHIA-COLI; SULFATE-REDUCING BACTERIA; CHAIN FATTY-ACIDS; INTESTINAL MICROBIOTA; FECAL MICROBIOTA; MOUSE MODEL; MINERAL METABOLISM; GLUCOSE-METABOLISM;
D O I：
10.1186/s13213-023-01744-5
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
BackgroundThe gut microbiota plays a crucial role in regulating the host's immune responses during aging, which was characterized by a different abundance of bacteria in several age groups.Main bodyGut microbiota dysbiosis is associated with aging, antibiotic exposure, underlying diseases, infections, hormonal variations, circadian rhythm, and malnutrition, either singularly or in combination. The appropriate use of prebiotics and probiotics may be able to prevent or reduce this disruption.ConclusionThe current review focuses on the gut microbiota composition across the life cycle, factors affecting gut microbiota changes with aging, and interventions to modulate gut microbiota.
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页数：24
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共 288 条
  • [91] Immunomodulation by food: impact on gut immunity and immune cell function
    Hachimura, Satoshi
    Totsuka, Mamoru
    Hosono, Akira
    [J]. BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 2018, 82 (04) : 584 - 599
  • [92] Hamady M, 2008, NAT METHODS, V5, P235, DOI [10.1038/nmeth.1184, 10.1038/NMETH.1184]
  • [93] Obesity and weight management in the elderly
    Han, T. S.
    Tajar, Abdelouahid
    Lean, M. E. J.
    [J]. BRITISH MEDICAL BULLETIN, 2011, 97 (01) : 169 - 196
  • [94] The Human Gut Microbiota
    Harmsen, Hermie J. M.
    de Goffau, Marcus. C.
    [J]. MICROBIOTA OF THE HUMAN BODY: IMPLICATIONS IN HEALTH AND DISEASE, 2016, 902 : 95 - 108
  • [95] Impact of lifestyle on the gut microbiota of healthy infants and their mothers - the ALADDIN birth cohort
    Hesla, Helena M.
    Stenius, Fredrik
    Jaderlund, Lotta
    Nelson, Ronald
    Engstrand, Lars
    Alm, Johan
    Dicksved, Johan
    [J]. FEMS MICROBIOLOGY ECOLOGY, 2014, 90 (03) : 791 - 801
  • [96] Dispersal strategies shape persistence and evolution of human gut bacteria
    Hildebrand, Falk
    Gossmann, Toni, I
    Frioux, Clemence
    Ozkurt, Ezgi
    Myers, Pernille Neve
    Ferretti, Pamela
    Kuhn, Michael
    Bahram, Mohammad
    Nielsen, Henrik Bjorn
    Bork, Peer
    [J]. CELL HOST & MICROBE, 2021, 29 (07) : 1167 - +
  • [97] Evolution of gut microbiota composition from birth to 24 weeks in the INFANTMET Cohort
    Hill, Cian J.
    Lynch, Denise B.
    Murphy, Kiera
    Ulaszewska, Marynka
    Jeffery, Ian B.
    O'Shea, Carol Anne
    Watkins, Claire
    Dempsey, Eugene
    Mattivi, Fulvio
    Tuohy, Kieran
    Ross, R. Paul
    Ryan, C. Anthony
    Toole, Paul W. O'
    Stanton, Catherine
    [J]. MICROBIOME, 2017, 5
  • [98] The International Scientific Association for Probiotics and Prebiotics consensus statement on the scope and appropriate use of the term probiotic
    Hill, Colin
    Guarner, Francisco
    Reid, Gregor
    Gibson, Glenn R.
    Merenstein, Daniel J.
    Pot, Bruno
    Morelli, Lorenzo
    Canani, Roberto Berni
    Flint, Harry J.
    Salminen, Seppo
    Calder, Philip C.
    Sanders, Mary Ellen
    [J]. NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY, 2014, 11 (08) : 506 - 514
  • [99] Meta-analysis of effects of exclusive breastfeeding on infant gut microbiota across populations
    Ho, Nhan T.
    Li, Fan
    Lee-Sarwar, Kathleen A.
    Tun, Hein M.
    Brown, Bryan P.
    Pannaraj, Pia S.
    Bender, Jeffrey M.
    Azad, Meghan B.
    Thompson, Amanda L.
    Weiss, Scott T.
    Azcarate-Peril, M. Andrea
    Litonjua, Augusto A.
    Kozyrskyj, Anita L.
    Jaspan, Heather B.
    Aldrovandi, Grace M.
    Kuhn, Louise
    [J]. NATURE COMMUNICATIONS, 2018, 9
  • [100] MOLECULAR ORIGINS OF CANCER DNA Damage, Aging, and Cancer
    Hoeijmakers, Jan H. J.
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2009, 361 (15) : 1475 - 1485
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