The role of gut microbiota in human metabolism and inflammatory diseases: a focus on elderly individuals

被引：12
作者：
Khaledi, Mansoor [1 ,2 ]
Poureslamfar, Behnam [3 ]
Alsaab, Hashem O. [4 ]
Tafaghodi, Shahrad [5 ]
Hjazi, Ahmed [6 ]
Singh, Rajesh [7 ]
Alawadi, Ahmed Hussien [8 ]
Alsaalamy, Ali [9 ]
Qasim, Qutaiba A. [10 ]
Sameni, Fatemeh [1 ]
机构：
[1] Shahed Univ, Fac Med, Dept Microbiol, Tehran, Iran
[2] Shahrekord Univ Med Sci, Sch Med, Dept Microbiol & Immunol, Shahrekord, Iran
[3] Univ Yasuj, Fac Sci, Dept Biol, Yasuj, Iran
[4] Taif Univ, Dept Pharmaceut & Pharmaceut Technol, Taif 21944, Saudi Arabia
[5] Isfahan Univ Med Sci, Dept Clin Biochem, Sch Pharm & Pharmaceut Sci, Esfahan, Iran
[6] Prince Sattam Bin Abdulaziz Univ, Coll Appl Med Sci, Dept Med Lab Sci, Al Kharj 11942, Saudi Arabia
[7] Uttaranchal Univ, Uttaranchal Inst Technol, Dept Elect & Commun Engn, Dehra Dun 248007, India
[8] Islamic Univ, Coll Tech Engn, Najaf, Iraq
[9] Imam Jaafar Al Sadiq Univ, Coll Tech Engn, Al Muthanna 66002, Iraq
[10] Al Ayen Univ, Coll Pharm, Thi Qar, Iraq
来源：
ANNALS OF MICROBIOLOGY | 2024年 / 74卷 / 01期
关键词：
Gut microbiota; Aging; Inflammatory disease; Metabolism; Probiotic; CLOSTRIDIUM-DIFFICILE INFECTION; MITOCHONDRIAL-DNA MUTATIONS; INVASIVE ESCHERICHIA-COLI; SULFATE-REDUCING BACTERIA; CHAIN FATTY-ACIDS; INTESTINAL MICROBIOTA; FECAL MICROBIOTA; MOUSE MODEL; MINERAL METABOLISM; GLUCOSE-METABOLISM;
D O I：
10.1186/s13213-023-01744-5
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
BackgroundThe gut microbiota plays a crucial role in regulating the host's immune responses during aging, which was characterized by a different abundance of bacteria in several age groups.Main bodyGut microbiota dysbiosis is associated with aging, antibiotic exposure, underlying diseases, infections, hormonal variations, circadian rhythm, and malnutrition, either singularly or in combination. The appropriate use of prebiotics and probiotics may be able to prevent or reduce this disruption.ConclusionThe current review focuses on the gut microbiota composition across the life cycle, factors affecting gut microbiota changes with aging, and interventions to modulate gut microbiota.
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页数：24
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