Macrophage phenotypes and functions: resolving inflammation and restoring homeostasis

被引：47

作者：

Rodriguez-Morales, Patricia ^{[1
]}

Franklin, Ruth A. ^{[1
,2
]}

机构：

[1] Harvard Med Sch, Dept Immunol, Boston, MA 02115 USA

[2] Harvard Univ, Dept Stem Cell & Regenerat Biol, Cambridge, MA 02138 USA

来源：

TRENDS IN IMMUNOLOGY | 2023年 / 44卷 / 12期

基金：

美国国家卫生研究院; 美国国家科学基金会;

关键词：

CAVITY MACROPHAGES; HOST RECOVERY; FIBROSIS; MECHANISMS; CLEARANCE; REGENERATION; DISTINCT; HEALTH; REPAIR; NICHE;

D O I：

10.1016/j.it.2023.10.004

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Inflammation must be tightly regulated to both defend against pathogens and re -store tissue homeostasis. The resolution of inflammatory responses is a dynamic process orchestrated by cells of the immune system. Macrophages, tissue-resident innate immune cells, are key players in modulating inflammation. Here, we review recent work highlighting the importance of macrophages in tissue res-olution and the return to homeostasis. We propose that enhancing macrophage pro-resolution functions represents a novel and widely applicable therapeutic strategy to dampen inflammation, promote repair, and restore tissue integrity and function.

引用

页码：986 / 998

页数：13

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