Novel Insights into Prokineticin 1 Role in Pregnancy-related Diseases

被引：2
作者：
Cheng, Xi-Xi [1 ,2 ]
Li, Ming-Qing [3 ,4 ,5 ]
Peng, Ting [1 ,2 ]
机构：
[1] Shanghai Changning Matern & Infant Hlth Hosp, Shanghai, Peoples R China
[2] Fudan Univ, Shanghai Obstet & Gynecol Hosp, Dept Obstet, Shanghai 200080, Peoples R China
[3] Fudan Univ, Hosp Obstet & Gynecol, Shanghai Inst Planned Parenthood Res, NHC Key Lab Reprod Regulat, Shanghai 200080, Peoples R China
[4] Fudan Univ, Hosp Obstet & Gynecol, Shanghai Key Lab Female Reprod Endocrine Related D, Shanghai 200080, Peoples R China
[5] Fudan Univ, Hosp Obstet & Gynecol, Inst Obstet & Gynecol, Lab Reprod Immunol, Shanghai 200080, Peoples R China
来源：
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES | 2024年 / 21卷 / 01期
基金：
中国国家自然科学基金;
关键词：
prokineticin1; maternal-fetal interface; angiogenesis; recurrent miscarriage; preeclampsia; fetal growth restriction; ENDOTHELIAL-GROWTH-FACTOR; PROTEIN-COUPLED RECEPTORS; EG-VEGF; MOLECULAR CHARACTERIZATION; PORCINE ENDOMETRIUM; 1ST TRIMESTER; PPAR-GAMMA; CELL-LINE; EXPRESSION; GENE;
D O I：
10.7150/ijms.76817
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Prokineticin 1 (PROK1) is a secreted protein involved in a range of physiological activities such as cell proliferation, migration, angiogenesis, and neuronal cell proliferation. Emerging evidences show that PROK1/PROK receptors (PROKRs) are expressed by trophoblasts, and decidual stroma cells at the maternal-fetal interface. PROK1 plays a critical role in successful pregnancy establishment by regulating the decidualization, implantation and placental development. Dysregulation of prokineticin signaling has been described in certain pathological states associated with pregnancy, including pre-eclampsia, recurrent miscarriage and fetal growth restriction. In this review, the expression and pleiotropic roles of PROK1 under physiological and pathological pregnancy conditions are discussed.
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收藏
页码：27 / 36
页数：10
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