Impact of Atrial Fibrillation on Patients Undergoing Transcatheter Aortic Valve Implantation (TAVI): The K-TAVI Registry

被引：8

作者：

Lee, Sang Yoon ^{[1
]}

Choi, Ki Hong ^{[1
]}

Park, Taek Kyu ^{[1
]}

Kim, Jihoon ^{[1
]}

Kim, Eun Kyoung ^{[1
]}

Park, Sung-Ji ^{[1
]}

Park, Seung Woo ^{[1
]}

Gwon, Hyeon-Cheol ^{[1
]}

Chang, Kiyuk ^{[2
]}

Yu, Cheol Woong ^{[3
]}

Kim, JuHan ^{[4
]}

Choi, Young Jin ^{[5
]}

Chae, In-Ho ^{[6
]}

Lee, Jae-Hwan ^{[7
]}

Kim, Jun-Hong ^{[8
,9
]}

Park, Jong Seon ^{[10
]}

Kim, Won-Jang ^{[11
]}

Yoon, Young Won ^{[12
]}

Ahn, Tae Hoon ^{[13
]}

Lee, Sang Rok ^{[14
]}

Choi, Byoung Joo ^{[15
]}

Yang, Tae-Hyun ^{[16
]}

Choi, Cheol Ung ^{[17
]}

Hur, Seung-Ho ^{[18
]}

Oh, Seong-Jin ^{[19
]}

Lee, Han Cheol ^{[20
,21
]}

Park, HunSik ^{[22
]}

Kim, Hyo-Soo ^{[23
]}

Choi, Seung-Hyuk ^{[1
]}

机构：

[1] Sungkyunkwan Univ Sch Med, Heart Vasc Stroke Inst, Div Cardiol, Dept Internal Med,Samsung Med Ctr, Seoul, South Korea

[2] Catholic Univ Korea, Seoul St Marys Hosp, Div Cardiol, Dept Internal Med, Seoul, South Korea

[3] Korea Univ, Div Cardiol, Dept Internal Med, Cardiovasc Ctr,Anam Hosp, Seoul, South Korea

[4] Heart Ctr Chonnam Natl Univ Hosp, Gwangju, South Korea

[5] Sejong Gen Hosp, Cardiovasc Ctr, Cardiol, Bucheon, South Korea

[6] Seoul Natl Univ, Div Cardiol, Dept Internal Med, Bundang Hosp, Seongnam, South Korea

[7] Chungnam Natl Univ, Sch Med, Dept Cardiol, Chungnam Natl Univ Hosp, Daejeon, South Korea

[8] Pusan Natl Univ, Div Cardiol, Dept Internal Med, Yangsan Hosp, Busan, South Korea

[9] Pusan Natl Univ, Res Inst Convergence Biomed Sci & Technol, Yangsan Hosp, Busan, South Korea

[10] Yeungnam Univ Hosp, Dept Med, Daegu, South Korea

[11] CHA Univ, CHA Bundang Med Ctr, Dept Cardiol, Seongnam, South Korea

[12] Yonsei Univ, Gangnam Severance Hosp, Heart Ctr, Div Cardiol,Coll Med, Seoul, South Korea

[13] Gachon Univ, Cardiol, Gil Med Ctr, Incheon, South Korea

[14] Chonbuk Natl Univ Hosp, Dept Internal Med, Div Cardiol, Jeonju, South Korea

[15] Ajou Univ, Dept Cardiol, Med Ctr, Suwon, South Korea

[16] Univ Inje, Busan Paik Hosp, Dept Cardiol, Coll Med, Busan, South Korea

[17] Korea Univ, Coll Med, Div Cardiol, Dept Internal Med,Guro Hosp,Cardiovasc Ctr, Seoul, South Korea

[18] Keimyung Univ, Dept Internal Med, Dongsan Med Ctr, Daegu, South Korea

[19] Ilsan Hosp, Div Cardiol, Natl Hlth Insurance Serv, Goyang, South Korea

[20] Pusan Natl Univ Hosp, Dept Cardiol, Busan, South Korea

[21] Pusan Natl Univ Hosp, Med Res, Busan, South Korea

[22] Kyungpook Natl Univ Hosp, Dept Internal Med, Daegu, South Korea

[23] Seoul Natl Univ Hosp, Cardiol Ctr, Dept Internal Med, Seoul, South Korea

来源：

YONSEI MEDICAL JOURNAL | 2023年 / 64卷 / 07期

关键词：

Transcatheter aortic valve implantation; atrial fibrillation; Korean; antithrombotic agent; PERMANENT PACEMAKER IMPLANTATION; PREDICTIVE FACTORS; PROGNOSTIC VALUE; REPLACEMENT; OUTCOMES; STENOSIS; SOCIETY;

D O I：

10.3349/ymj.2022.0649

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Purpose: The incidence and prognostic implications of atrial fibrillation (AF) in patients with severe aortic stenosis (AS) undergo-ing transcatheter aortic valve implantation (TAVI) are controversial, especially for Korean patients. Furthermore, the pattern of an-tithrombotic therapy for these patients is unknown. The present study sought to identify the impact of AF on Korean patients un-dergoing TAVI and demonstrate the status of antithrombotic therapy for these patients.Materials and Methods: A total of 660 patients who underwent TAVI for severe AS were recruited from the nationwide K-TAVI registry in Korea. The enrolled patients were stratified into sinus rhythm (SR) and AF groups. The primary endpoint was all-cause death at 1-year.Results: AF was recorded in 135 patients [pre-existing AF 108 (16.4%) and new-onset AF 27 (4.1%)]. The rate of all-cause death at 1 year was significantly higher in patients with AF than in those with SR [16.2% vs. 6.4%, adjusted hazard ratio (HR): 2.207, 95% con-fidence interval (CI): 1.182-4.120, p=0.013], regardless of the onset timing of AF. The rate of new pacemaker insertion at 1 year was also significantly higher in patients with AF than in those with SR (14.0% vs. 5.5%, adjusted HR: 3.137, 95%CI: 1.621-6.071, p=0.001). Among AF patients, substantial number of patients received the combination of multiple antithrombotic agents (77.8%), and the most common combination was that of aspirin and clopidogrel (38.1%).Conclusion: AF was an independent predictor of 1-year mortality and new pacemaker insertion in Korean patients undergoing TAVI.

引用

页码：413 / 422

页数：10

共 24 条

[1] Incidence, Predictive Factors, and Prognostic Value of New-Onset Atrial Fibrillation Following Transcatheter Aortic Valve Implantation [J].

Amat-Santos, Ignacio J. ;

Rodes-Cabau, Josep ;

Urena, Marina ;

DeLarochelliere, Robert ;

Doyle, Daniel ;

Bagur, Rodrigo ;

Villeneuve, Jacques ;

Cote, Melanie ;

Nombela-Franco, Luis ;

Philippon, Francois ;

Pibarot, Philippe ;

Dumont, Eric .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2012, 59 (02) :178-188

[2] Atrial Fibrillation Is Associated With Increased Mortality in Patients Undergoing Transcatheter Aortic Valve Replacement Insights From the Placement of Aortic Transcatheter Valve (PARTNER) Trial [J].

Biviano, Angelo B. ;

Nazif, Tamim ;

Dizon, Jose ;

Garan, Hasan ;

Fleitman, Jessica ;

Hassan, Dua ;

Kapadia, Samir ;

Babaliaros, Vasilis ;

Xu, Ke ;

Parvataneni, Rupa ;

Rodes-Cabau, Josep ;

Szeto, Wilson Y. ;

Fearon, William F. ;

Dvir, Danny ;

Dewey, Todd ;

Williams, Mathew ;

Mack, Michael J. ;

Webb, John G. ;

Miller, D. Craig ;

Smith, Craig R. ;

Leon, Martin B. ;

Kodali, Susheel .

CIRCULATION-CARDIOVASCULAR INTERVENTIONS, 2016, 9 (01)

[3]

Camm AJ, 2010, EUROPACE, V12, P1360, DOI [10.1093/europace/euq350, 10.1093/eurheartj/ehq278]

[4] Baseline Characteristics and Prognostic Implications of Pre-Existing and New-Onset Atrial Fibrillation After Transcatheter Aortic Valve Implantation Results From the FRANCE-2 Registry [J].

Chopard, Romain ;

Teiger, Emmanuel ;

Meneveau, Nicolas ;

Chocron, Sidney ;

Gilard, Martine ;

Laskar, Marc ;

Eltchaninoff, Helene ;

Iung, Bernard ;

Leprince, Pascal ;

Chevreul, Karine ;

Prat, Alain ;

Lievre, Michel ;

Leguerrier, Alain ;

Donzeau-Gouge, Patrick ;

Fajadet, Jean ;

Mouillet, Gauthier ;

Schiele, Francois .

JACC-CARDIOVASCULAR INTERVENTIONS, 2015, 8 (10) :1346-1355

[5] Incidence, Predictors, and Outcomes of Permanent Pacemaker Implantation Following Transcatheter Aortic Analysis From the US Society of Thoracic Surgeons/American College of Cardiology TVT Registry [J].

Fadahunsi, Opeyemi O. ;

Olowoyeye, Abiola ;

Ukaigwe, Anene ;

Li, Zhuokai ;

Vora, Amit N. ;

Vemulapalli, Sreekanth ;

Elgin, Eric ;

Donato, Anthony .

JACC-CARDIOVASCULAR INTERVENTIONS, 2016, 9 (21) :2189-2199

[6] New-Onset Postoperative Atrial Fibrillation and Long-Term Survival After Aortic Valve Replacement Surgery [J].

Filardo, Giovanni ;

Hamilton, Cody ;

Hamman, Baron ;

Hebeler, Robert F., Jr. ;

Adams, John ;

Grayburn, Paul .

ANNALS OF THORACIC SURGERY, 2010, 90 (02) :474-480

[7]

Harold JG, 2014, J AM COLL CARDIOL, V63, pE57, DOI [10.1016/j.jacc.2014.02.536, 10.1016/j.jtcvs.2014.05.014, 10.1016/j.jacc.2014.02.537]

[8]

Jorgensen TH, 2015, J INVASIVE CARDIOL, V27, P41

[9] Insights Into Timing, Risk Factors, and Outcomes of Stroke and Transient Ischemic Attack After Transcatheter Aortic Valve Replacement in the PARTNER Trial (Placement of Aortic Transcatheter Valves) [J].

Kapadia, Samir ;

Agarwal, Shikhar ;

Miller, D. Craig ;

Webb, John G. ;

Mack, Michael ;

Ellis, Stephen ;

Herrmann, Howard C. ;

Pichard, Augusto D. ;

Tuzcu, E. Murat ;

Svensson, Lars G. ;

Smith, Craig R. ;

Rajeswaran, Jeevanantham ;

Ehrlinger, John ;

Kodali, Susheel ;

Makkar, Raj ;

Thourani, Vinod H. ;

Blackstone, Eugene H. ;

Leon, Martin B. .

CIRCULATION-CARDIOVASCULAR INTERVENTIONS, 2016, 9 (09)

[10]

Kappetein AP, 2012, J AM COLL CARDIOL, V60, P1438, DOI [10.1016/j.jacc.2012.09.001, 10.1093/ejcts/ezs533]

← 1 2 3 →