Micelle formation and physico-chemical variables for the sodium dodecyl sulfate/cetylpyridinium chloride and their mixture in aqueous propranolol hydrochloride drug solvent: Conductivity and theoretical analysis

Herein, study of both single and mixed micelle development of an anionic surfactant sodium dodecyl sulfate (SDS) and a cationic surfactant cetylpyridinium chloride (CPC) in propranolol hydrochloride (PPH) drug medium has been performed using a conductometric technique at different temperatures and compositions. The critical micelle concentration (CMC) along with degree of ionization (g) were assessed from the specific conductivity (j) versus [surfactant] plots. Within the concentration of surfactant studied, a single CMC was achieved in the situations of pure and mixed surfactant micellization. The CMC and g values have been noticed reliant on the employed drug concentrations, variations of mole fractions of the mixture of surfactants and experimental temperature. For the micellization of single SDS/ CPC surfactants in aq. PPH drug medium, PPH drug causes delayed micelle development which has been detected as the upsurge of CMC values of SDS/CPC in PPH drug media. For the association of SDS/ CPC surfactants in aq. PPH drug medium, the CMC values experienced a lessening with the growth of study temperature. At a fixed temperature, the experimental CMC values, of the SDS + CPC mixture, endure a decline through the upsurge of mole fractions of CPC (a1), attain a minimum value and the CMC values tend to enhance at and above a1 = 16.2 x 10-5. The ideal critical micelle concentrations (CMCid) are detected always as higher values than experimental CMC up to the a1 = 10.8 x 10-5. The -b values and |b| > |ln(CMC1/ CMC2)| for the present study reveal that the interaction among the amphiphiles under analysis is synergistic. The negative free energy (-DGOm) of micellization were obtained throughout the study. The enthalpy (DHOm) and entropy (DSOm) of micellization reveal the presence of hydrophobic interaction as the principal type of interaction among the studied constituents. The negative excess free energy (DGex) values inferred that stable mixed micelles are formed for the mixture of SDS + CPC in aq. PPH drug medium. The micellar mole fractions (both experimental and ideal values), activity coefficients of components in mixed micelles as well as enthalpy-entropy compensation parameters were also measured and illustrated. It is possible that the knowledge gained from the current analysis may be used to enhance pharmaceutical formulations, drug delivery carriers, along with drug act proficiency.(c) 2023 Elsevier B.V. All rights reserved.