Causal role of a neural system for separating and selecting multidimensional social cognitive information

被引：7

作者：

Mahmoodi, Ali ^{[1
]}

Nili, Hamed ^{[1
,2
]}

Harbison, Caroline ^{[1
]}

Hamilton, Sorcha ^{[1
]}

Trudel, Nadescha ^{[1
,3
,4
]}

Bang, Dan ^{[4
,5
,6
]}

Rushworth, Matthew F. S. ^{[1
,6
]}

机构：

[1] Univ Oxford, Wellcome Ctr Integrat Neuroimaging, Dept Expt Psychol, Oxford, England

[2] Univ Med Ctr Hamburg Eppendorf UKE, Ctr Mol Neurobiol ZMNH, Dept Excellence Neural Informat Proc, Hamburg, Germany

[3] Max Planck UCL Ctr Computat Psychiat & Ageing Res, London, England

[4] Univ Coll London, Wellcome Ctr Human Neuroimaging, Oxford, England

[5] Univ Oxford, Dept Expt Psychol, Oxford, England

[6] Aarhus Univ, Ctr Functionally Integrat Neurosci, Aarhus, Denmark

来源：

NEURON | 2023年 / 111卷 / 07期

基金：

英国惠康基金;

关键词：

SELF-OTHER MERGENCE; FRONTAL-LOBE; REPRESENTATIONS; NAVIGATION; CORTEX; MAP; KNOWLEDGE;

D O I：

10.1016/j.neuron.2022.12.030

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

People are multi-faceted, typically good at some things but bad at others, and a critical aspect of social judgement is the ability to focus on those traits relevant for the task at hand. However, it remains unknown how the brain supports such context-dependent social judgement. Here, we examine how people represent multidimensional individuals, and how the brain extracts relevant information and filters out irrelevant infor-mation when comparing individuals within a specific dimension. Using human fMRI, we identify distinct neu-ral representations in dorsomedial prefrontal cortex (dmPFC) and anterior insula (AI) supporting separation and selection of information for context-dependent social judgement. Causal evaluation using non-invasive brain stimulation shows that AI disruption alters the impact of relevant information on social comparison, whereas dmPFC disruption only affects the impact of irrelevant information. This neural circuit is distinct from the one supporting integration across, as opposed to separation of, different features of a multidimen-sional cognitive space.

引用

页码：1152 / +

页数：20

共 42 条

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