Comparison of the Relative Sensitivity of Clinical, Endoscopic, and Histologic Remission for Detection of Treatment Efficacy in Ulcerative Colitis Trials

被引：1
作者：
Sedano, Rocio [1 ,2 ]
Hogan, Malcolm [2 ]
Zou, Guangyong [2 ]
Narula, Neeraj [3 ]
Singh, Siddharth [4 ]
Ma, Christopher [2 ,5 ,6 ]
Feagan, Brian G. [1 ,2 ,7 ]
Jairath, Vipul [1 ,2 ,7 ]
机构：
[1] Western Univ, Dept Med, Div Gastroenterol, London, ON, Canada
[2] Alimentiv Inc, London, ON, Canada
[3] McMaster Univ, Farncombe Family Digest Hlth Res Inst, Dept Med, Div Gastroenterol, Hamilton, ON, Canada
[4] Univ Calif San Diego, Div Gastroenterol, La Jolla, CA 92093 USA
[5] Univ Calgary, Dept Med, Div Gastroenterol & Hepatol, Calgary, AB, Canada
[6] Univ Calgary, Dept Community Hlth Sci, Calgary, AB, Canada
[7] Western Univ, Dept Epidemiol & Biostat, London, ON, Canada
来源：
INFLAMMATORY BOWEL DISEASES | 2023年 / 29卷 / 02期
关键词：
ulcerative colitis; clinical trials; remission; outcome sensitivity; treatment efficacy; MAINTENANCE THERAPY; INDUCTION;
D O I：
10.1093/ibd/izac128
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
Lay Summary This systemic review and quantitative analysis of placebo-controlled ulcerative colitis (UC) induction trials found higher pooled histologic remission rates compared with clinical and endoscopic remission rates at the same timepoint, and no significant differences in pooled relative risks for these outcomes between treatment groups; supporting the concept that histologic remission is not less sensitive than clinical or endoscopic remission.
引用
收藏
页码：324 / 327
页数：4
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