Anxiolytic-like effects of extremely low frequency electric field in stressed rats: involvement of 5-HT2C receptors

被引:2
作者
Kantar, Deniz [1 ]
Acun, Alev Duygu [1 ]
Er, Hakan [2 ]
Afsar, Ebru [3 ]
Yargicoglu, Piraye [1 ]
机构
[1] Akdeniz Univ, Fac Med, Dept Biophys, TR-07070 Antalya, Turkey
[2] Akdeniz Univ, Vocat Sch Hlth Serv, Dept Med Imaging Tech, Antalya, Turkey
[3] Istanbul Kultur Univ, Fac Hlth Sci, Dept Nutr & Dietet, Istanbul, Turkey
关键词
Stress; low frequency electric field; serotonin; auditory evoked potentials; anxiety; social interaction; SOCIAL ANXIETY DISORDER; SEROTONIN; EXPOSURE; AGONIST; AGOMELATINE; ANTAGONIST; MODULATION; ACTIVATION; BINDING; ACTH;
D O I
10.1080/09553002.2022.2087929
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
Background Possible modulatory effects of noninvasive brain stimulation have gained interest recently. In our study, the effect of low frequency electric fields (LF-EF) on stress-induced electrophysiological, behavioral changes and the possible involvement of serotonergic 5-HT2C receptors were investigated. Materials and methods A total of eight groups including the control groups were formed by applying LF-EF with or without a 5-HT2C receptor agonist to naive or acute stress exposed rats to demonstrate the effects of LF-EF. LF-EF administration at 10 kV/m was started 30 min before acute stress application and lasted for 1 h in total. Anxiety levels and social interaction were evaluated using the elevated plus maze test and social interaction test, respectively. Auditory evoked potentials (AEP) were recorded by using ascending loudness paradigms. Loudness dependence AEP (LDAEP) was calculated by using amplitude values to analyze serotonergic transmission. Serotonin and glucocorticoid levels were measured in the frontal cortex and hippocampus. Results It was observed that the applied LF-EF reduced the anxiety behavior, and attenuated the LDAEP responses in stress and/or 5-HT2C receptor agonist applied groups. In parallel, an increase in serotonin levels and a decrease in glucocorticoid levels were observed. However, LF-EF exposure was ineffective in impaired social interaction. Conclusions Our findings show that 10 kV/m LF-EF administration may modulate the neural network and physiological responses associated with mild acute stress. 5-HT2C receptor dependent functions are thought to play a role in the anxiolytic effect of LF-EF.
引用
收藏
页码:1473 / 1482
页数:10
相关论文
共 42 条
  • [1] Anxiogenic effects in the rat elevated plus-maze of 5-HT2C agonists into ventral but not dorsal hippocampus
    Alves, SH
    Pinheiro, G
    Motta, V
    Landeira-Fernandez, J
    Cruz, APM
    [J]. BEHAVIOURAL PHARMACOLOGY, 2004, 15 (01): : 37 - 43
  • [2] How is the brain working? Research on brain oscillations and connectivities in a new "Take-Off" state
    Basar, Erol
    Duzgun, Aysel
    [J]. INTERNATIONAL JOURNAL OF PSYCHOPHYSIOLOGY, 2016, 103 : 3 - 11
  • [3] Cortisol modulates men's affiliative responses to acute social stress
    Berger, Justus
    Heinrichs, Markus
    von Dawans, Bernadette
    Way, Baldwin M.
    Chen, Frances S.
    [J]. PSYCHONEUROENDOCRINOLOGY, 2016, 63 : 1 - 9
  • [4] Stress leads to prosocial action in immediate need situations
    Buchanan, Tony W.
    Preston, Stephanie D.
    [J]. FRONTIERS IN BEHAVIORAL NEUROSCIENCE, 2014, 8
  • [5] Reduced social interaction following 3,4-methylenedioxymethamphetamine is not associated with enhanced 5-HT2C receptor responsivity
    Bull, EJ
    Hutson, PH
    Fone, KCF
    [J]. NEUROPHARMACOLOGY, 2003, 44 (04) : 439 - 448
  • [6] Corticosterone after acute stress prevents the delayed effects on the amygdala
    Chakraborty, Prabahan
    Datta, Siddhartha
    McEwen, Bruce S.
    Chattarji, Sumantra
    [J]. NEUROPSYCHOPHARMACOLOGY, 2020, 45 (13) : 2139 - 2146
  • [7] SEROTONIN FUNCTION IN ANXIETY .2. EFFECTS OF THE SEROTONIN AGONIST MCPP IN PANIC DISORDER PATIENTS AND HEALTHY-SUBJECTS
    CHARNEY, DS
    WOODS, SW
    GOODMAN, WK
    HENINGER, GR
    [J]. PSYCHOPHARMACOLOGY, 1987, 92 (01) : 14 - 24
  • [8] Collimore KC, 2010, DEPRESS ANXIETY, V27, P1017, DOI [10.1002/da.20771, 10.1002/da.20759]
  • [9] DEBRUYN L, 1994, ENVIRON RES, V65, P149, DOI 10.1006/enrs.1994.1028
  • [10] Citalopram reduces social interaction in rats by activation of serotonin (5-HT)2C receptors
    Dekeyne, A
    Denorme, B
    Monneyron, S
    Millan, MJ
    [J]. NEUROPHARMACOLOGY, 2000, 39 (06) : 1114 - 1117