Updated grading system for systemic allergic reactions: Joint Statement of the World Allergy Organization Anaphylaxis Committee and Allergen Immunotherapy Committee

被引：11

作者：

Turner, Paul J. ^{[1
,28
]}

Ansotegui, Ignacio J. ^{[2
]}

Campbell, Dianne E. ^{[3
,4
]}

Cardona, Victoria ^{[5
]}

Carr, Stuart ^{[6
]}

Custovic, Adnan ^{[1
]}

Durham, Stephen ^{[1
]}

Ebisawa, Motohiro ^{[7
]}

Geller, Mario ^{[8
]}

Gonzalez-Estrada, Alexei ^{[9
]}

Greenberger, Paul A. ^{[10
]}

Hossny, Elham ^{[11
]}

Irani, Carla ^{[12
]}

Leung, Agnes S. Y. ^{[13
]}

Levin, Michael E. ^{[14
]}

Muraro, Antonella ^{[15
]}

Oppenheimer, John J. ^{[16
]}

Martell, Jose Antonio Ortega ^{[17
]}

Pouessel, Guillaume ^{[18
,19
]}

Rial, Manuel J. ^{[20
]}

Senna, Gianenrico ^{[21
]}

Tanno, Luciana K. ^{[22
,23
,24
]}

Wallace, Dana V. ^{[25
]}

Worm, Margitta ^{[26
]}

Morais-Almeida, Mario ^{[27
]}

机构：

[1] Imperial Coll London, Natl Heart & Lung Inst, London, England

[2] Hosp Quironsalud Bizkaia, Dept Allergy & Immunol, Bilbao, Spain

[3] Univ Sydney, Sydney Med Sch, Discipline Paediat & Child Hlth, Sydney, Australia

[4] DBV Technol, Montrouge, France

[5] Hosp Univ Vall dHebron, Dept Internal Med, Allergy Sect, Barcelona, Spain

[6] Sno Asthma & Allergy, Abu Dhabi, U Arab Emirates

[7] Natl Hosp Org, Sagamihara Natl Hosp, Clin Res Ctr Allergy & Rheumatol, Dept Allergy, Kanagawa, Japan

[8] Acad Med Rio de Janeiro, Div Med, Rio De Janeiro, Brazil

[9] Mayo Clin, Dept Med, Div Allergy Asthma & Clin Immunol, Scottsdale, AZ USA

[10] Northwestern Univ, Feinberg Sch Med, Dept Med, Div Allergy & Immunol, Chicago, IL USA

[11] Ain Shams Univ, Childrens Hosp, Pediat Allergy & immunol unit, Cairo, Egypt

[12] St Joseph Univ, Hotel Dieu France Hosp, Beirut, Lebanon

[13] Chinese Univ Hong Kong, Prince Wales Hosp, Dept Paediat, Shatin, Hong Kong, Peoples R China

[14] Univ Cape Town, Dept Paediat, Div Paediat Allergy, Cape Town, South Africa

[15] Padua Univ Hosp, Food Allergy Referral Ctr, Dept Woman & Child Hlth, Padua, Italy

[16] Rutgers New Jersey Med Sch, Atlantic Hlth Syst Morristown, Newark, NJ USA

[17] Univ Autonoma Estado Hidalgo, Hidalgo, Mexico

[18] Childrens Hosp, Dept Paediat, Roubaix, France

[19] CHU Lille, Hop Jeanne de Flandre, Paediat Pulmonol & Allergy Dept, Lille, France

[20] Complexo Hosp Univ A Coruna, Allergy Dept, La Coruna, Spain

[21] Verona Univ & Gen Hosp, Asthma Ctr & Allergy Unit, Verona, Italy

[22] Hosp Sirio Libanes, Sao Paulo, Brazil

[23] Univ Hosp Montpellier, Montpellier, France

[24] Sorbonne Univ, Paris, France

[25] Nova Southeastern Univ, Coll Allopath Med, Ft Lauderdale, FL USA

[26] Charite, Dept Dermatol & Allergol, Berlin, Germany

[27] CUF Descobertas Hosp, Allergy Ctr, Lisbon, Portugal

[28] Imperial Coll London, Natl Heart & Lung Inst, Norfolk Pl, London W2 1PG, England

来源：

WORLD ALLERGY ORGANIZATION JOURNAL | 2024年 / 17卷 / 03期

基金：

英国医学研究理事会;

关键词：

Adverse events; Allergen immunotherapy; Anaphylaxis; Clinical trials; Safety reporting; SEVERITY;

D O I：

10.1016/j.waojou.2024.100876

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

There is a lack of consensus over the description and severity assignment of allergic adverse reactions to immunotherapy, although there seems to be a consensus at least in terms of using the World Allergy Organization (WAO) grading systems to describe local adverse events for Sublingual Immunotherapy (SLIT) and Systemic Allergic Reactions (SARs) to Subcutaneous Immunotherapy (SCIT) amongst the major national/regional allergy societies. In this manuscript, we propose a modification of the previous WAO Grading system for SARs, which aligns with the newly-proposed Consortium for Food Allergy Research (CoFAR) Grading Scale for Systemic Allergic Reactions in Food Allergy (version 3.0). We hope this can facilitate a unified grading system appropriate to SARs due to allergen immunotherapy, independent of allergen and route of administration, and across clinical and research practice.

引用

页数：9

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