ING4 and ING5 are essential for histone H3 lysine 14 acetylation and epicardial cell lineage development

被引：5

作者：

Mah, Sophia Y. Y. ^{[1
,2
]}

Vanyai, Hannah K. ^{[1
,2
]}

Li-Wai-Suen, Connie S. N. ^{[1
,2
]}

Garnham, Alexandra L. ^{[1
,2
]}

Wynn, Jessica ^{[1
,2
]}

Bergamasco, Maria I. ^{[1
,2
]}

Malelang, Shezlie ^{[1
]}

Wilcox, Stephen ^{[1
,2
]}

Biben, Christine ^{[1
,2
]}

Smyth, Gordon K. ^{[1
,3
]}

Thomas, Tim ^{[1
,2
]}

Voss, Anne K. ^{[1
,2
]}

机构：

[1] Walter & Eliza Hall Inst Med Res, Epigenet & Dev Div, Melbourne, Vic 3052, Australia

[2] Univ Melbourne, Dept Med Biol, Melbourne, Vic 3052, Australia

[3] Univ Melbourne, Sch Math & Stat, Parkville, Vic 3010, Australia

来源：

DEVELOPMENT | 2024年 / 151卷 / 05期

基金：

英国医学研究理事会;

关键词：

Inhibitor of growth proteins; ING4; ING5; Histone acetylation; Heart development; PHD FINGER; MOLECULAR-MECHANISM; PLANT HOMEODOMAIN; CRYSTAL-STRUCTURE; GENE-EXPRESSION; BINDING; ACETYLTRANSFERASE; GROWTH; MUTATIONS; COMPLEX;

D O I：

10.1242/dev.202617

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Inhibitor of growth 4 and 5 (ING4, ING5) are structurally similar chromatin-binding proteins in the KAT6A, KAT6B and KAT7 histone acetyltransferase protein complexes. Heterozygous mutations in the KAT6A or KAT6B gene cause human disorders with cardiac defects, but the contribution of their chromatin-adaptor proteins to development is unknown. We found that Ing5(-/-) mice had isolated cardiac ventricular septal defects. Ing4(-/- )Ing5(-/-) embryos failed to undergo chorioallantoic fusion and arrested in development at embryonic day 8.5, displaying loss of histone H3 lysine 14 acetylation, reduction in H3 lysine 23 acetylation levels and reduced developmental gene expression. Embryonic day 12.5 Ing4(+/-)Ing5(-/-) hearts showed a paucity of epicardial cells and epicardium-derived cells, failure of myocardium compaction, and coronary vasculature defects, accompanied by reduced expression of epicardium genes. Cell adhesion gene expression and proepicardium outgrowth were defective in the ING4- and ING5-deficient state. Our findings suggest that ING4 and ING5 are essential for heart development and promote epicardium and epicardium-derived cell fates and imply mutation of the human ING5 gene as a possible cause of isolated ventricular septal defects.

引用

页数：19

共 93 条

[1] ACETYLATION + METHYLATION OF HISTONES + THEIR POSSIBLE ROLE IN REGULATION OF RNA SYNTHESIS [J].

ALLFREY, VG ;

FAULKNER, R ;

MIRSKY, AE .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1964, 51 (05) :786-+

[2] Wt1 controls retinoic acid signalling in embryonic epicardium through transcriptional activation of Raldh2 [J].

Antonio Guadix, Juan ;

Ruiz-Villalba, Adrian ;

Lettice, Laura ;

Velecela, Victor ;

Munoz-Chapuli, Ramon ;

Hastie, Nicholas D. ;

Maria Perez-Pomares, Jose ;

Martinez-Estrada, Ofelia M. .

DEVELOPMENT, 2011, 138 (06) :1093-1097

[3] De Novo Nonsense Mutations in KAT6A, a Lysine Acetyl-Transferase Gene, Cause a Syndrome Including Microcephaly and Global Developmental Delay [J].

Arboleda, Valerie A. ;

Lee, Hane ;

Dorrani, Naghmeh ;

Zadeh, Neda ;

Willis, Mary ;

Macmurdo, Colleen Forsyth ;

Manning, Melanie A. ;

Kwan, Andrea ;

Hudgins, Louanne ;

Barthelemy, Florian ;

Miceli, M. Carrie ;

Quintero-Rivera, Fabiola ;

Kantarci, Sibel ;

Strom, Samuel P. ;

Deignan, Joshua L. ;

Grody, Wayne W. ;

Vilain, Eric ;

Nelson, Stanley F. .

AMERICAN JOURNAL OF HUMAN GENETICS, 2015, 96 (03) :498-506

[4] Gene Ontology: tool for the unification of biology [J].

Ashburner, M ;

Ball, CA ;

Blake, JA ;

Botstein, D ;

Butler, H ;

Cherry, JM ;

Davis, AP ;

Dolinski, K ;

Dwight, SS ;

Eppig, JT ;

Harris, MA ;

Hill, DP ;

Issel-Tarver, L ;

Kasarskis, A ;

Lewis, S ;

Matese, JC ;

Richardson, JE ;

Ringwald, M ;

Rubin, GM ;

Sherlock, G .

NATURE GENETICS, 2000, 25 (01) :25-29

[5] Inhibitors of histone acetyltransferases KAT6A/B induce senescence and arrest tumour growth [J].

Baell, Jonathan B. ;

Leaver, David J. ;

Hermans, Stefan J. ;

Kelly, Gemma L. ;

Brennan, Margs S. ;

Downer, Natalie L. ;

Nguyen, Nghi ;

Wichmann, Johannes ;

Mcrae, Helen M. ;

Yang, Yuqing ;

Cleary, Ben ;

Lagiakos, H. Rachel ;

Mieruszynski, Stephen ;

Pacini, Guido ;

Vanyai, Hannah K. ;

Bergamasco, Maria I. ;

May, Rose E. ;

Davey, Bethany K. ;

Morgan, Kimberly J. ;

Sealey, Andrew J. ;

Wang, Beinan ;

Zamudio, Natasha ;

Wilcox, Stephen ;

Garnham, Alexandra L. ;

Sheikh, Bilal N. ;

Aubrey, Brandon J. ;

Doggett, Karen ;

Chung, Matthew C. ;

de Silva, Melanie ;

Bentley, John ;

Pilling, Pat ;

Hattarki, Meghan ;

Dolezal, Olan ;

Dennis, Matthew L. ;

Falk, Hendrik ;

Ren, Bin ;

Charman, Susan A. ;

White, Karen L. ;

Rautela, Jai ;

Newbold, Andrea ;

Hawkins, Edwin D. ;

Johnstone, Ricky W. ;

Huntington, Nicholas D. ;

Peat, Thomas S. ;

Heath, Joan K. ;

Strasser, Andreas ;

Parker, Michael W. ;

Smyth, Gordon K. ;

Street, Ian P. ;

Monahan, Brendon J. .

NATURE, 2018, 560 (7717) :253-+

[6] Mutations in KAT6B, Encoding a Histone Acetyltransferase, Cause Genitopatellar Syndrome [J].

Campeau, Philippe M. ;

Kim, Jaeseung C. ;

Lu, James T. ;

Schwartzentruber, Jeremy A. ;

Abdul-Rahman, Omar A. ;

Schlaubitz, Silke ;

Murdock, David M. ;

Jiang, Ming-Ming ;

Lammer, Edward J. ;

Enns, Gregory M. ;

Rhead, William J. ;

Rowland, Jon ;

Robertson, Stephen P. ;

Cormier-Daire, Valerie ;

Bainbridge, Matthew N. ;

Yang, Xiang-Jiao ;

Gingras, Marie-Claude ;

Gibbs, Richard A. ;

Rosenblatt, David S. ;

Majewski, Jacek ;

Lee, Brendan H. .

AMERICAN JOURNAL OF HUMAN GENETICS, 2012, 90 (02) :282-289

[7] Epicardium in Heart Development [J].

Cao, Yingxi ;

Duca, Sierra ;

Cao, Jingli .

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY, 2020, 12 (02)

[8] The crystal structure of the ING5 PHD finger in complex with an H3K4me3 histone peptide [J].

Champagne, Karen S. ;

Saksouk, Nehme ;

Pena, Pedro V. ;

Johnson, Kyle ;

Ullah, Mukta ;

Yang, Xiang-Jiao ;

Cote, Jacques ;

Kutateladze, Tatiana G. .

PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS, 2008, 72 (04) :1371-1376

[9] Epicardial induction of fetal cardiomyocyte proliferation via a retinoic acid-inducible trophic factor [J].

Chen, THP ;

Chang, TC ;

Kang, JO ;

Choudhary, B ;

Makita, T ;

Tran, CM ;

Burch, JBE ;

Eid, H ;

Sucov, HM .

DEVELOPMENTAL BIOLOGY, 2002, 250 (01) :198-207

[10] Adult Cardiac-Resident MSC-like Stem Cells with a Proepicardial Origin [J].

Chong, James J. H. ;

Chandrakanthan, Vashe ;

Xaymardan, Munira ;

Asli, Naisana S. ;

Li, Joan ;

Ahmed, Ishtiaq ;

Heffernan, Corey ;

Menon, Mary K. ;

Scarlett, Christopher J. ;

Rashidianfar, Amirsalar ;

Biben, Christine ;

Zoellner, Hans ;

Colvin, Emily K. ;

Pimanda, John E. ;

Biankin, Andrew V. ;

Zhou, Bin ;

Pu, William T. ;

Prall, Owen W. J. ;

Harvey, Richard P. .

CELL STEM CELL, 2011, 9 (06) :527-540

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