MYC expression and fatty acid oxidation in EGFR-TKI acquired resistance

被引：1
作者：
Wang, GuoSheng [1 ,2 ]
Li, Tao [3 ,4 ]
Wan, Yuan [2 ,5 ]
Li, Qiang [1 ]
机构：
[1] Tongji Univ, Shanghai East Hosp, Sch Med, Dept Pulm & Crit Care Med, Shanghai 200120, Peoples R China
[2] SUNY Binghamton, Pq Lab Micro Nano BiomeDx, Dept Biomed Engn, Binghamton, NY 13902 USA
[3] Nantong Univ, Affiliated Tumor Hosp, Dept Med Oncol, 30 Tongyang Bei Rd, Nantong 226361, Peoples R China
[4] Nantong Tumor Hosp, 30 Tongyang Bei Rd, Nantong 226361, Peoples R China
[5] SUNY Binghamton, BI2625,Biotechnol Bldg,65 Murray Hill Rd, Vestal, NY 13850 USA
来源：
DRUG RESISTANCE UPDATES | 2024年 / 72卷
关键词：
EGFR-TKI resistance; T cell; MYC; Fatty acid metabolism; Lung cancer; T-CELLS; MECHANISMS; IMMUNITY; THERAPY; CD47;
D O I：
10.1016/j.drup.2023.101019
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
This report expands on our previous research, highlighting a unique inverse correlation between MYC expression in tumor cells and immune cells during the development of EGFR-TKI resistance. It is observed that MYC expression and fatty acid oxidation (FAO) metabolism in tissue-resident memory (TRM) CD8 + T cells are significantly impaired. These findings offer new insights into the mechanisms of TKI resistance. Although the study is preliminary, it suggests caution when interpreting the effectiveness of MYC inhibitors in reversing TKI resistance, especially when immune factors are not considered.
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页数：5
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