Comparative neurogenetics of dog behavior complements efforts towards human neuropsychiatric genetics

被引：4

作者：

Morrill, Kathleen ^{[1
,2
,3
]}

Chen, Frances ^{[1
,2
]}

Karlsson, Elinor ^{[1
,2
]}

机构：

[1] Univ Massachusetts, Bioinformat & Integrat Biol, Chan Med Sch, Worcester, MA 01655 USA

[2] Broad Inst MIT & Harvard, Vertebrate Genome Biol, Cambridge, MA 02142 USA

[3] UMass Chan Med Sch, Morningside Grad Sch Biomed Sci, Worcester, MA 01655 USA

来源：

HUMAN GENETICS | 2023年 / 142卷 / 08期

关键词：

GENOME-WIDE ASSOCIATION; OBSESSIVE-COMPULSIVE DISORDER; COGNITIVE DYSFUNCTION; ALZHEIMERS-DISEASE; CANINE BRAIN; PSYCHIATRIC-DISORDERS; BREED DISTRIBUTION; ANIMAL-MODELS; RISK-FACTORS; QUESTIONNAIRE;

D O I：

10.1007/s00439-023-02580-y

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Domestic dogs display a wide array of heritable behaviors that have intermediate genetic complexity thanks to a long history of human-influenced selection. Comparative genetics in dogs could address the scarcity of non-human neurogenetic systems relevant to human neuropsychiatric disorders, which are characterized by mental, emotional, and behavioral symptoms and involve vastly complex genetic and non-genetic risk factors. Our review describes the diverse behavioral "phenome" of domestic dogs, past and ongoing sources of behavioral selection, and the state of canine behavioral genetics. We highlight two naturally disordered behavioral domains that illustrate how dogs may prove useful as a comparative, forward neurogenetic system: canine age-related cognitive dysfunction, which can be examined more rapidly given the attenuated lifespan of dogs, and compulsive disorders, which may have genetic roots in purpose-bred behaviors. Growing community science initiatives aimed at the companion dog population will be well suited to investigating such complex behavioral phenotypes and offer a comparative resource that parallels human genomic initiatives in scale and dimensionality.

引用

页码：1231 / 1246

页数：16