Metal-free, an effective and one-pot protocol for the reductive amination of aldehydes using glycerol as a green solvent

A novel, green, catalyst-free, and efficient method has been developed for the one-pot reductive amination of carbonyl compounds using sodium borohydride. This method has performed reductive amination on various functionalized amines and aldehydes, including aliphatic, aromatic, and heteroaromatic compounds. The reductive amination of the carbonyl compounds occurred in a single step without any side reaction. The key benefits of this technique included its easiness, greener protocol, quick transformation, variety of substrates, high yield, metal-free, and solvent recyclability. This helps to make the procedure practical, affordable, and biodegradable.