Metal-free, an effective and one-pot protocol for the reductive amination of aldehydes using glycerol as a green solvent

被引：9

作者：

Patil, Shripad M. ^{[1
,2
]}

Bedre, Ashwini, V ^{[2
]}

Gade, Vilas B. ^{[3
]}

Jopale, Manohar K. ^{[4
]}

机构：

[1] Lovely Profess Univ, Sch Chem Engn & Phys Sci, Phagwara 144411, Punjab, India

[2] Dada Patil Mahavidyalaya, Savitribai Phule Pune Univ, Karjat 414401, Maharashtra, India

[3] Rayat Shikshan Sansthas Arts Sci & Commerce Coll, Dept Chem, Palghat 401604, Maharashtra, India

[4] MVP Samajs Arts Commerce & Sci Coll, Dept Chem, Nasik 422212, Maharashtra, India

来源：

JOURNAL OF CHEMICAL SCIENCES | 2023年 / 135卷 / 02期

关键词：

Aldehydes; Amines; Sodium borohydrides; Glycerol; Green reaction condition; CATALYST-FREE SYNTHESIS; CARBONYL-COMPOUNDS; SELECTIVE REDUCTION; EFFICIENT SYNTHESIS; SODIUM-BOROHYDRIDE; ZINC BOROHYDRIDE; SECONDARY-AMINES; KETONES; IMINES; HYDRIDE;

D O I：

10.1007/s12039-023-02172-3

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A novel, green, catalyst-free, and efficient method has been developed for the one-pot reductive amination of carbonyl compounds using sodium borohydride. This method has performed reductive amination on various functionalized amines and aldehydes, including aliphatic, aromatic, and heteroaromatic compounds. The reductive amination of the carbonyl compounds occurred in a single step without any side reaction. The key benefits of this technique included its easiness, greener protocol, quick transformation, variety of substrates, high yield, metal-free, and solvent recyclability. This helps to make the procedure practical, affordable, and biodegradable.

引用

页数：10

共 50 条

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