Prognostic implications of histologic growth patterns and tumor-infiltrating macrophages in colorectal liver metastases

被引:6
作者
Takahashi, Yuki [1 ]
Matsuo, Kenichi [1 ,2 ]
Shiozawa, Toshimitsu [1 ]
Suzuki, Kaori [1 ]
Shimizu, Hiroaki [2 ]
Tanaka, Kuniya [1 ,2 ]
机构
[1] Showa Univ, Dept Gen & Gastroenterol Surg, Fujigaoka Hosp, 1 30 Fujigaoka, Aoba Ku, Yokohama, Kanagawa 2278501, Japan
[2] Teikyo Univ, Dept Surg, Chiba Med Ctr, Ichihara, Japan
关键词
Liver metastases; Colorectal cancer; Hepatectomy; Tumor growth pattern; CANCER; POLARIZATION; INFLAMMATION; INVASION; CELLS; ADENOCARCINOMAS; PROGRESSION; RECURRENCE; EXPRESSION; PLASTICITY;
D O I
10.1007/s00423-022-02741-z
中图分类号
R61 [外科手术学];
学科分类号
摘要
PurposeHistopathologic patterns at the invasion fronts of tumors predict metastatic potential and prognosis in several cancers. We examined whether such patterns at the interface between colorectal liver metastases and hepatic parenchyma have similar prognostic value.MethodsMicroscopic growth patterns at edges of metastases including desmoplasia, pushing borders, and replacement of hepatocytes were retrospectively analyzed with respect to surgical outcomes in 142 patients who underwent hepatectomy for colorectal metastases.ResultsPatterns included desmoplasia in 58 patients (41%), hepatocyte replacement in 41 (29%), and pushing borders in 43 (30%). Maximum metastasis diameter and serum carcinoembryonic antigen concentration in patients showing desmoplastic tumor growth were lower than those in others (P < 0.05 and P < 0.01). Disease-free survival and overall survival were better in patients showing desmoplastic growth, while a non-desmoplastic tumor growth pattern showed a negative influence. More cluster of differentiation (CD) 68-positive M1 macrophages and fewer CD206-positive M2 macrophages were demonstrated at interfaces of tumors with hepatic parenchyma when desmoplasia was present, although markers for proliferative activity (MIB1 index) and metastatic potential (E-cadherin expression) appeared uninfluenced by desmoplasia.ConclusionBetter long-term results were associated with metastatic tumors showing desmoplastic growth patterns at invasion fronts, which may reflect local immune state in a prognostically useful manner.
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页数:10
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共 37 条
[1]   Inflammation and cancer: back to Virchow? [J].
Balkwill, F ;
Mantovani, A .
LANCET, 2001, 357 (9255) :539-545
[2]   The role of tumour-associated macrophages in tumour progression: implications for new anticancer therapies [J].
Bingle, L ;
Brown, NJ ;
Lewis, CE .
JOURNAL OF PATHOLOGY, 2002, 196 (03) :254-265
[3]   Loss of E-cadherin promotes the growth, invasion and drug resistance of colorectal cancer cells and is associated with liver metastasis [J].
Chen, Xiaobing ;
Wang, Yongsheng ;
Xia, Hongping ;
Wang, Qiwu ;
Jiang, Xiaochun ;
Lin, Zihong ;
Ma, Yuedong ;
Yang, Yang ;
Hu, Minghua .
MOLECULAR BIOLOGY REPORTS, 2012, 39 (06) :6707-6714
[4]   Macrophages: Obligate partners for tumor cell migration, invasion, and metastasis [J].
Condeelis, J ;
Pollard, JW .
CELL, 2006, 124 (02) :263-266
[5]   Inflammation and cancer [J].
Coussens, LM ;
Werb, Z .
NATURE, 2002, 420 (6917) :860-867
[6]  
de Visser KE, 2006, CONTRIB MICROBIOL, V13, P118, DOI 10.1159/000092969
[7]   The interplay between innate and adaptive immunity regulates cancer development [J].
de Visser, KE ;
Coussens, LM .
CANCER IMMUNOLOGY IMMUNOTHERAPY, 2005, 54 (11) :1143-1152
[8]   Inflammation and uPAR-Expression in Colorectal Liver Metastases in Relation to Growth Pattern and Neo-adjuvant Therapy [J].
Eefsen, R. L. ;
Engelholm, L. ;
Alpizar-Alpizar, W. ;
Van den Eynden, G. G. E. ;
Vermeulen, P. B. ;
Christensen, I. J. ;
Laerum, O. D. ;
Rolff, H. C. ;
Hoyer-Hansen, G. ;
Vainer, B. ;
Osterlind, K. ;
Illemann, M. .
CANCER MICROENVIRONMENT, 2015, 8 (02) :93-100
[9]   Growth pattern of colorectal liver metastasis as a marker of recurrence risk [J].
Eefsen, R. L. ;
Vermeulen, P. B. ;
Christensen, I. J. ;
Laerum, O. D. ;
Mogensen, M. B. ;
Rolff, H. C. ;
Van den Eynden, G. G. ;
Hoyer-Hansen, G. ;
Osterlind, K. ;
Vainer, B. ;
Illemann, M. .
CLINICAL & EXPERIMENTAL METASTASIS, 2015, 32 (04) :369-381
[10]   Histopathological Growth Pattern, Proteolysis and Angiogenesis in Chemonaive Patients Resected forMultiple Colorectal LiverMetastases [J].
Eefsen, Rikke Lovendahl ;
Van den Eynden, Gert G. ;
Hoyer-Hansen, Gunilla ;
Brodt, Pnina ;
Laerum, Ole Didrik ;
Vermeulen, Peter B. ;
Christensen, Ib Jarle ;
Wettergren, Andre ;
Federspiel, Birgitte ;
Willemoe, Gro L. ;
Vainer, Ben ;
Osterlind, Kell ;
Illemann, Martin .
JOURNAL OF ONCOLOGY, 2012, 2012