Sex Differences in Arteriovenous Fistula Failure: Insights from Bioinformatics Analysis

被引:3
作者
Hu, Ke [1 ]
Li, Yiqing [1 ]
Guo, Yi [2 ,3 ]
Cheng, Peng [4 ]
Li, Yuxuan [1 ]
Lu, Chanjun [1 ]
Cai, Chuanqi [1 ]
Wang, Weici [1 ]
机构
[1] Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Dept Vasc Surg, Wuhan 430000, Peoples R China
[2] Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Clin Ctr Human Gene Res, Wuhan 430000, Peoples R China
[3] Huazhong Univ Sci & Technol, Liyuan Hosp, Tongji Med Coll, Cardiovasc Ctr, Wuhan 430000, Peoples R China
[4] Hubei Univ Med, Taihe Hosp, Affiliated Hosp, Dept Nephrol, Shiyan 442000, Peoples R China
基金
中国国家自然科学基金;
关键词
sex differences; AVF failure; bioinformatics; SMOOTH-MUSCLE-CELLS; VASCULAR ACCESS; NEOINTIMAL HYPERPLASIA; HEMODIALYSIS-PATIENTS; MATURATION; IDENTIFICATION; INVOLVEMENT; CREATION; OUTCOMES;
D O I
10.3390/jcdd10010003
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
(1) Background: Arteriovenous fistulas (AVFs) are the preferred access for hemodialysis. Unfortunately, about 60% of patients, especially female patients, fail to receive normal dialysis within one year after surgery because of AVF failure. However, the underlying mechanisms caused by sex differences in AVF failure remain unclear. (2) Methods: We performed analysis of DEGs and functional analysis with the dataset GSE119296 to reveal the biology underlying AVF failure. Immune responses were calculated using CIBERSORT. A protein-protein interaction network and hub gene were constructed using STRING and stepwise identification of potential drugs was performed online. (3) Results: Functional analysis showed that extracellular matrix reprogramming and PI3K-AKT pathway enrichment were significant in both male and female patients. COL1A1 was the hub gene in male patients, whereas CDK1 was the hub gene in female patients. Immune responses including gamma delta-T cells and mast cells are activated in female patients while no significant differences were noted in the male group. (4) Conclusions: In this study, we used a series of mature and recognized bioinformatic strategies to determine the following items: (1) Reveal the pathogenesis of AVF failure through HUB genes and signaling pathways between the different sexes. (2) Determine the relationship between sex differences in AVF failure and immune abnormalities. (3) Search for relevant sex-specific drugs targeting AVF failure.
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页数:19
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