Enzymatic blood group conversion of human kidneys during ex vivo normothermic machine perfusion

被引：14

作者：

MacMillan, Serena ^{[1
]}

Hosgood, Sarah A. ^{[1
]}

Nicholson, Michael L. ^{[1
]}

机构：

[1] Univ Cambridge, Dept Surg, Cambridge, England

来源：

BRITISH JOURNAL OF SURGERY | 2023年 / 110卷 / 02期

关键词：

ANTIGEN; STRATEGIES;

D O I：

10.1093/bjs/znac293

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

A major restriction to transplantation is the requirement for ABO blood group compatibility between donor and recipient. In this study, an alpha-galactosidase enzyme from Bacteroides fragilis was used successfully to remove type B blood group antigens enzymatically from human kidneys using ex vivo normothermic machine perfusion. This provides the first step for a strategy to overcome the ABO barrier in kidney transplantation.

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收藏

页码：133 / 137

页数：5

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