The prolactin receptor gene (PRLR) is linked and associated with the risk of polycystic ovarian syndrome

被引：4
|
作者：
Amin, Mutaz [1 ]
Gragnoli, Claudia [2 ,3 ,4 ]
机构：
[1] INSERM, US14 Orphanet, Paris, France
[2] Creighton Univ, Sch Med, Dept Med, Div Rheumatol, Omaha, NE 68124 USA
[3] Penn State Coll Med, Dept Publ Hlth Sci, Hershey, PA 17033 USA
[4] Bios Biotech Multidiagnost Hlth Ctr, Mol Biol Lab, I-00197 Rome, Italy
来源：
JOURNAL OF OVARIAN RESEARCH | 2023年 / 16卷 / 01期
关键词：
Prolactin; PRL; Prolactin receptor; PRLR; Gene; Expression; Polycystic ovarian syndrome; PCOS; Ovary; Cortisol; Hypothalamic-pituitary-ovarian axis; HPO-axis; Metabolic; Insulin resistance; IR; Obesity; Type; 2; diabetes; T2D; Families; Familial; Peninsular; Italy; Italian; Parametric analysis; Linkage disequilibrium; Association; Single nucleotide polymorphisms; SNP; Risk; Variant; Model; Dominant; Recessive; Penetrance; Complete; Incomplete; Irregular menses; Oligomenorrhea; Subfertility; Folliculogenesis; Fat metabolism; Ethnic group; Appetite; Energy expenditure; Estrous cycle length; Follicle luteinization; Maturation; Metabolism; Adrenal; Steroidogenesis; Anovulation; Testosterone; Hyperandrogenism; Hyperandrogenemia; Endocrine; Disorder; Women; Reproductive age; Impaired glucose metabolism; Milk production; Social bonding; Genotyping; Mendelian; PLINK; Pseudomarker; Miscarriage; Recurrent; Depression; Rotterdam diagnostic criteria; Identical twins; Uncertain paternity; Generation; Endometrium; Obese; RegulomeDB; Control; rs13436213; rs1604428; REVISED; 2003; CONSENSUS; DIAGNOSTIC-CRITERIA; SECRETION;
D O I：
10.1186/s13048-023-01280-5
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
The prolactin receptor gene (PRLR) may contribute to polycystic ovarian syndrome (PCOS) since it plays important roles in physiological ovarian functions. PRLR-knockout mice have irregular cycles and subfertility and variants in or around the PRLR gene were associated in humans with female testosterone levels and recurrent miscarriage. We tested 40 variants in the PRLR gene in 212 Italian families phenotyped by type 2 diabetes (T2D) and PCOS and found two intronic PRLR-variants (rs13436213 and rs1604428) significantly linked to and/or associated with the risk of PCOS. This is the first study to report PRLR as a novel risk gene in PCOS. Functional studies are needed to confirm these results.
引用
收藏
页数：3
相关论文
共 50 条
  • [31] Review on bisphenol A and the risk of polycystic ovarian syndrome: an insight from endocrine and gene expression
    Mukhopadhyay, Risani
    Prabhu, Navya B.
    Kabekkodu, Shama Prasada
    Rai, Padmalatha S.
    ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH, 2022, 29 (22) : 32631 - 32650
  • [32] Serum spexin, adiponectin and leptin levels in polycystic ovarian syndrome in association with FTO gene polymorphism
    Beyazit, Fatma
    Hiz, Merve Meliha
    Turkon, Hakan
    Unsal, Mesut Abdulkerim
    GINEKOLOGIA POLSKA, 2021, 92 (10) : 682 - 688
  • [33] Metformin and Troglitazone in the Treatment of Female Infertility Associated with Polycystic Ovarian Syndrome
    Sangraula, H.
    Paudel, K. R.
    Sharma, M.
    JOURNAL OF NEPAL MEDICAL ASSOCIATION, 2009, 48 (04) : 335 - 339
  • [34] Scaffold-Free Endometrial Organoids Respond to Excess Androgens Associated With Polycystic Ovarian Syndrome
    Wiwatpanit, Teerawat
    Murphy, Alina R.
    Lu, Zhenxiao
    Urbanek, Margrit
    Burdette, Joanna E.
    Woodruff, Teresa K.
    Kim, J. Julie
    JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2020, 105 (03) : 769 - 780
  • [35] Genetic Variation in the Mcp-1 Gene Promoter Associated with the Risk of Polycystic Ovary Syndrome
    Li, Lan
    Ryoo, Ji Eun
    Lee, Kyung-Ju
    Choi, Bum-Chae
    Baek, Kwang-Hyun
    PLOS ONE, 2015, 10 (04):
  • [36] INSULIN, INDEPENDENT OF SERUM ANDROGENS OR ANDROGEN RECEPTOR CAG REPEAT POLYMORPHISM, IS ASSOCIATED WITH HIRSUTISM IN POLYCYSTIC OVARY SYNDROME
    Baculescu, N.
    Radian, S.
    Gussi, I. L.
    Gheorghiu, M.
    Coculescu, M.
    ACTA ENDOCRINOLOGICA-BUCHAREST, 2012, 8 (03) : 413 - 425
  • [37] Ovarian HMW adiponectin is associated with folliculogenesis in women with polycystic ovary syndrome
    Tao, Tao
    Xu, Bing
    Liu, Wei
    REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY, 2013, 11
  • [38] Association of gene polymorphisms in prolactin and its receptor with breast cancer risk in Taiwanese women
    Mong, Fan-Yun
    Kuo, Yu-Liang
    Liu, Ching-Wen
    Liu, Wen-Sheng
    Chang, Li-Ching
    MOLECULAR BIOLOGY REPORTS, 2011, 38 (07) : 4629 - 4636
  • [39] Independent predictors of cardiovascular risk in polycystic ovarian syndrome
    Turkcuoglu, Ilgin
    Kafkasli, Ayse
    Meydanli, Mehmet Mutlu
    Ozyalin, Fatma
    Taskapan, Cagatay
    GYNECOLOGICAL ENDOCRINOLOGY, 2011, 27 (11) : 915 - 919
  • [40] Polycystic ovarian syndrome is linked to increased oxidative stress in Omani women
    Sulaiman, Maha A. H.
    Al-Farsi, Yahya M.
    Al-Khaduri, Maha M.
    Saleh, Jumana
    Waly, Mostafa, I
    INTERNATIONAL JOURNAL OF WOMENS HEALTH, 2018, 10 : 763 - 771
12345