Metastasis in renal cell carcinoma: Biology and treatment

被引：5
作者：
Kanwal, Rafiah [1 ]
机构：
[1] Univ Management & Technol, Dept Life Sci, Lahore, Pakistan
来源：
ADVANCES IN CANCER BIOLOGY-METASTASIS | 2023年 / 7卷
关键词：
Renal cell carcinoma; Bone metastasis; Adrenal metastasis; Brain metastasis; Pancreas metastasis; Gallbladder metastasis; VEGF; mTOR; TRANSFORMING-GROWTH-FACTOR; HORMONE-RELATED PROTEIN; BLIND PHASE-III; INTERFERON-ALPHA; RADICAL NEPHRECTOMY; CYTOREDUCTIVE NEPHRECTOMY; GALLBLADDER METASTASIS; PANCREATIC METASTASES; PROGNOSTIC-FACTORS; TARGETED THERAPY;
D O I：
10.1016/j.adcanc.2023.100094
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Renal cell carcinoma (RCC) is a heterogeneous group of cancer that reacts inappropriately to recent therapeutic methods and is frequently linked with an uncertain clinical channel. The biology of renal cell carcinoma (RCC) depends on histology, tumor diversity, and the biological mechanism of metastasis. Malignant renal cell carcinoma (RCC) tumors can spread to bones, brain, pancreas, gallbladder, and adrenal gland resulting in metastasis. Medical treatment for renal cell carcinoma (RCC) has transformed from cytokine-based methods to targeted agent therapy against vascular endothelial growth factor (VEGF), and most recently to immunotherapy drugs. This review aims to summarize the biology of renal cell carcinoma and to understand the present and future directions in the treatment of metastasis.
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页数：7
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共 133 条
[51]  
2-G
[52]   Stage specific guidelines for surveillance after radical nephrectomy for local renal cell carcinoma [J].
Levy, DA ;
Slaton, JW ;
Swanson, DA ;
Dinney, CPN .
JOURNAL OF UROLOGY, 1998, 159 (04) :1163-1167
[53]  
Linehan W.M., 2016, N. Engl. J. Med., V374, P45
[54]   Matriptase: Potent proteolysis on the cell surface [J].
List, Karin ;
Bugge, Thomas H. ;
Szabo, Roman .
MOLECULAR MEDICINE, 2006, 12 (1-3) :1-7
[55]  
Ljungberg B, 1999, BJU INT, V84, P405
[56]   EAU Guidelines on Renal Cell Carcinoma: 2014 Update [J].
Ljungberg, Borje ;
Bensalah, Karim ;
Canfield, Steven ;
Dabestani, Saeed ;
Hofmann, Fabian ;
Hora, Milan ;
Kuczyk, Markus A. ;
Lam, Thomas ;
Marconi, Lorenzo ;
Merseburger, Axel S. ;
Mulders, Peter ;
Powles, Thomas ;
Staehler, Michael ;
Volpe, Alessandro ;
Bex, Axel .
EUROPEAN UROLOGY, 2015, 67 (05) :913-924
[57]   2004 WHO classification of the renal tumors of the adults [J].
Lopez-Beltran, A ;
Scarpelli, M ;
Rodolfo, M ;
Kirkali, Z .
EUROPEAN UROLOGY, 2006, 49 (05) :798-805
[58]   Neutrophil chemokines secreted by tumor cells mount a lung antimetastatic response during renal cell carcinoma progression [J].
Lopez-Lago, M. A. ;
Posner, S. ;
Thodima, V. J. ;
Molina, A. M. ;
Motzer, R. J. ;
Chaganti, R. S. K. .
ONCOGENE, 2013, 32 (14) :1752-1760
[59]   Genomic Characterization of Renal Cell Carcinoma with Sarcomatoid Dedifferentiation Pinpoints Recurrent Genomic Alterations [J].
Malouf, Gabriel G. ;
Ali, Siraj M. ;
Wang, Kai ;
Balasubramanian, Sohail ;
Ross, Jeffrey S. ;
Miller, Vincent A. ;
Stephens, Philip J. ;
Khayat, David ;
Pal, Sumanta K. ;
Su, Xiaoping ;
Sircar, Kanishka ;
Tamboli, Pheroze ;
Jonasch, Eric ;
Tannir, Nizar M. ;
Wood, Christopher G. ;
Karam, Jose A. .
EUROPEAN UROLOGY, 2016, 70 (02) :348-357
[60]   Parathyroid hormone-related protein is an essential growth factor for human clear cell renal carcinoma and a target for the von Hippel-Lindau tumor suppressor gene [J].
Massfelder, T ;
Lang, H ;
Schordan, E ;
Lindner, V ;
Rothhut, S ;
Welsch, S ;
Simon-Assmann, P ;
Barthelmebs, M ;
Jacqmin, D ;
Helwig, JJ .
CANCER RESEARCH, 2004, 64 (01) :180-188
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