An overview of limonoid synthetic derivatives as promising bioactive molecules

被引：4

作者：

Wang, Shaochi ^{[1
,2
]}

Kuperman, Laura L. ^{[3
,5
]}

Song, Zhihui ^{[3
]}

Chen, Yutian ^{[2
]}

Liu, Kun ^{[2
]}

Xia, Zongping ^{[2
]}

Xu, Yungen ^{[4
]}

Yu, Qiuning ^{[1
]}

机构：

[1] Zhengzhou Univ, Otorhinolaryngol Hosp, Affiliated Hosp 1, Zhengzhou 450052, Peoples R China

[2] Zhengzhou Univ, Translat Med Ctr, Affiliated Hosp 1, Zhengzhou 450052, Peoples R China

[3] Univ Maryland, Dept Chem & Biochem, College Pk, MD 20740 USA

[4] China Pharmaceut Univ, Dept Med Chem, Nanjing 210009, Jiangsu, Peoples R China

[5] Mirimus Inc, 760 Parkside Ave, Brooklyn, NY 11226 USA

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2023年 / 259卷

基金：

中国国家自然科学基金;

关键词：

ESTER DERIVATIVES; CITRUS LIMONOIDS; RECENT PROGRESS; AGENTS; INFLAMMATION; CHEMISTRY; OBACUNONE; LARVAE;

D O I：

10.1016/j.ejmech.2023.115704

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Limonoids, a class of abundant natural tetracyclic triterpenoids, present diverse biological activity and provide a versatile platform amenable by chemical modi-fications for clinical use. Among all of the limonoids isolated from natural sources, obacunone, nomilin, and limonin are the primary hub of limonoid-based chemical modification research. To date, more than 800 limonoids analogs have been synthesized, some of which possess promising biological activities. This review not only discusses the synthesis of limonoid derivatives as promising therapeutic candidates and details the pharmacological studies of their underlying mechanisms from 2002 to 2022, but also proposes a preliminary limonoid synthetic structure-activity relationship (SAR) and provides future direction of limonoid derivatization research.

引用

页数：10

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