Recent advances in analysis of capsaicin and its effects on metabolic pathways by mass spectrometry

被引:5
作者
Peng, Zifang [1 ]
Zhang, Wenfen [1 ,2 ]
Zhang, Xu [3 ]
Mao, Jian [2 ,4 ]
Zhang, Qidong [2 ,4 ]
Zhao, Wuduo [1 ]
Zhang, Shusheng [1 ,4 ]
Xie, Jianping [2 ,4 ]
机构
[1] Zhengzhou Univ, Coll Chem, Zhengzhou, Henan, Peoples R China
[2] Zhengzhou Tobacco Res Inst CNTC, Zhengzhou, Henan, Peoples R China
[3] Zhengzhou Univ, Sch Ecol & Environm, Zhengzhou, Henan, Peoples R China
[4] Zhengzhou Univ, Food Lab Zhongyuan, Flavor Sci Res Ctr, Luohe, Henan, Peoples R China
来源
FRONTIERS IN NUTRITION | 2023年 / 10卷
基金
中国博士后科学基金; 中国国家自然科学基金;
关键词
capsaicin; mass spectrometry; food analysis; metabolic pathways; biological activities; IDENTIFICATION; MS/MS;
D O I
10.3389/fnut.2023.1227517
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
Capsaicin is the main food active component in Capsicum that has gained considerable attention due to its broad biological activities, including antioxidation, anti-inflammation, anti-tumor, weight regulation, cardiac protection, anti-calculi, and diurnal-circadian regulation. The potent biological effects of capsaicin are intimately related to metabolic pathways such as lipid metabolism, energy metabolism, and antioxidant stress. Mass spectrometry (MS) has emerged as an effective tool for deciphering the mechanisms underlying capsaicin metabolism and its biological impacts. However, it remains challenging to accurately identify and quantify capsaicin and its self-metabolites in complex food and biological samples, and to integrate multi-omics data generated from MS. In this work, we summarized recent advances in the detection of capsaicin and its self-metabolites using MS and discussed the relevant MS-based studies of metabolic pathways. Furthermore, we discussed current issues and future directions in this field. In-depth studies of capsaicin metabolism and its physiological functions based on MS is anticipated to yield new insights and methods for preventing and treating a wide range of diseases.
引用
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页数:8
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