A 52-week multicenter retrospective real-world study on effectiveness and safety of dupilumab in children with atopic dermatitis aged from 6 to 11 years

被引：14

作者：

Patruno, Cataldo ^{[1
]}

Fabbrocini, Gabriella ^{[2
]}

Lauletta, Giuseppe ^{[2
]}

Boccaletti, Valeria ^{[3
]}

Colonna, Cristiana ^{[4
]}

Cavalli, Riccardo ^{[4
]}

Neri, Iria ^{[5
]}

Ortoncelli, Michela ^{[6
]}

Schena, Donatella ^{[7
]}

Stingeni, Luca ^{[8
]}

Hansel, Katharina ^{[8
]}

Piccolo, Vincenzo ^{[9
]}

Di Brizzi, Veronica ^{[9
]}

Potenza, Concetta ^{[10
]}

Tolino, Ersilia ^{[10
]}

Bianchi, Luca ^{[11
]}

Manti, Sara ^{[11
]}

De Pasquale, Rocco ^{[12
]}

Di Lernia, Vito ^{[13
]}

Caminiti, Lucia ^{[14
]}

Galli, Elena ^{[15
]}

Coppo, Paola ^{[16
]}

Chiricozzi, Andrea ^{[17
,18
]}

De Simone, Clara ^{[17
,18
]}

Guerriero, Cristina ^{[17
]}

Amoruso, Fabrizio Giuseppe ^{[19
]}

Provenzano, Eugenio ^{[19
]}

Leonardi, Salvatore ^{[20
]}

Licari, Amelia ^{[21
]}

Marseglia, Gian Luigi ^{[21
]}

Palermo, Antonino ^{[22
]}

Di Pillo, Sabrina ^{[23
]}

Russo, Daniele ^{[23
]}

Moschese, Viviana ^{[24
]}

Patella, Vincenzo ^{[25
]}

Peduto, Tiziana ^{[25
]}

Ferreli, Caterina ^{[26
]}

Zangari, Paola ^{[27
]}

Veronese, Federica ^{[28
]}

Berti, Samantha Federica ^{[29
]}

Gruber, Michaela ^{[30
]}

Pezzolo, Elena ^{[31
]}

Termine, Stefania ^{[32
]}

Satta, Rosanna ^{[33
]}

Dragoni, Federica ^{[34
]}

Esposito, Maria ^{[35
]}

Fargnoli, Maria Concetta ^{[35
]}

Chiodini, Paolo ^{[9
]}

Vallone, Ylenia ^{[2
]}

di Vico, Francesca ^{[2
]}

机构：

[1] Magna Graecia Univ Catanzaro, Dept Hlth Sci, Catanzaro, Italy

[2] Univ Naples Federico II, Dept Clin Med & Surg, Sect Dermatol, Naples, Italy

[3] Univ Brescia, Dept Med, Sect Dermatol, Brescia, Italy

[4] Fdn IRCCS Ca Granda Osped Maggiore Policlin, Dept Clin Sci & Community Hlth, Pediat Dermatol Unit, Milan, Italy

[5] Univ Bologna, Unit Dermatol, IRCCS AOU Policlin S Orsola, Bologna, Italy

[6] Univ Turin, Dept Med Sci, Div Dermatol, Turin, Italy

[7] Univ Verona, Dept Med, Sect Dermatol & Venereol, Verona, Italy

[8] Univ Perugia, Dept Med & Surg, Dermatol Sect, Perugia, Italy

[9] Univ Campania Luigi Vanvitelli, Dermatol Unit, Caserta, Italy

[10] Sapienza Univ Rome, Dept Med Surg Sci & Biotechnol, Dermatol Unit Daniele Innocenzi, Polo Pontino, Latina, Italy

[11] Univ Tor Vergata, Syst Med Dept, Dermatol Unit, Policlin Tor Vergata, Rome, Italy

[12] Osped San Marco, UO Dermatol, Catania, Italy

[13] Azienda USL IRCCS Reggio Emilia, Dermatol Unit, Arcispedale Santa Maria Nuova, Reggio Emilia, Italy

[14] Univ Messina, Policlin Hosp, Messina, Italy

[15] Osped San Pietro Fatebenefratelli, UOS Immuno Allergol Eta evolut, Rome, Italy

[16] Regina Margher Childrens Hosp Citta Salute & Sci T, Pediat Endocrinol Unit, Turin, Italy

[17] Fdn Policlin Univ A Gemelli IRCCS, Dipartimento Sci Med & Chirurg, Dermatol, Rome, Italy

[18] Univ Cattolica Sacro Cuore, Dipartimento Univ Med & Chirurg Traslazionale, Dermatol, Rome, Italy

[19] Azienda Osped Cosenza, Dermatol Unit, Cosenza, Italy

[20] Univ Catania, San Marco Hosp, Dept Clin & Expt Med, Pediat Resp Unit, Catania, Italy

[21] Univ Pavia, Fdn IRCCS Policlin San Matteo, Dept Pediat, Pediat Clin, Pavia, Italy

[22] Garibaldi Hosp, Dept Pediat, Catania, Italy

[23] Univ G dAnnunzio, Dept Pediat, Pediat Allergy & Pulmonol Unit, Chieti, Italy

[24] Univ Roma Tor Vergata, Pediat Allergol & Immunol Unit, Policlin Tor Vergata, Rome, Italy

[25] Santa Maria Speranza Hosp, Dept Med, Div Allergy & Clin Immunol, Battipaglia, SA, Italy

[26] Univ Cagliari, Dept Med Sci & Publ Hlth, Dermatol Clin, Cagliari, Italy

[27] Bambino Gesu Pediat Hosp, Acad Dept Pediat DPUO, Res Unit Clin Immunol & Vaccinol, IRCCS, Rome, Italy

[28] AOU Maggiore Car Hosp, Dermatol Clin, Novara, Italy

[29] Univ Florence, Dept Surg & Translat Med, Dermatol Unit, Florence, Italy

[30] Cent Hosp Bolzano, Dept Pediat, Bolzano, Italy

[31] Osped San Bortolo, Dermatol Unit, Vicenza, Italy

[32] Santa Chiara Hosp, Div Dermatol, Trento, Italy

[33] Univ Sassari, Dipartimento Sci Med Chirurg & Sperimentali, Sassari, Italy

[34] UOC Dermatol Osped San Donato, Arezzo, Italy

[35] Univ Aquila, Dept Biotechnol & Appl Clin Sci, Dermatol, Laquila, Italy

来源：

JOURNAL OF DERMATOLOGICAL TREATMENT | 2023年 / 34卷 / 01期

关键词：

Atopic dermatitis; children; dupilumab; real-world data;

D O I：

10.1080/09546634.2023.2246602

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Background: Dupilumab has been shown to be a safe and effective drug for the treatment of atopic dermatitis (AD) in children from 6 months to 11 years in randomized clinical trials. Aim: The aim of this real-life study was to determine the effectiveness in disease control and safety of dupilumab at W52 in moderate-to-severe AD children aged 6-11 years. Methods: All data were collected from 36 Italian dermatological or paediatric referral centres. Dupilumab was administered at label dosage with an induction dose of 300 mg on day 1 (D1), followed by 300 mg on D15 and 300 mg every 4 weeks (Q4W). Treatment effect was determined as overall disease severity, using EASI, P-NRS, S-NRS and c-DLQI at baseline, W16, W24, and W52. Ninety-six AD children diagnosed with moderate-to-severe AD and treated with dupilumab were enrolled. Results: Ninety-one (94.8%) patients completed the 52-week treatment period and were included in the study. A significant improvement in EASI score, P-NRS, S-NRS and c-DLQI was observed from baseline to weeks 16, 24 and 52. Conclusions: Our real-life data seem to confirm dupilumab effectiveness and safety in paediatric patients. Moreover, our experience highlighted that patients achieving clinical improvement at W16 preserved this condition over time.

引用

页数：6

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