The acute effects of repetitive transcranial magnetic stimulation on laminar diffusion anisotropy of neocortical gray matter

被引：3

作者：

Zhang, Wenjing ^{[1
,2
,3
,4
]}

Liu, Naici ^{[1
,2
,3
,4
]}

Zhao, Youjin ^{[1
,2
,3
,4
]}

Yao, Chenyang ^{[1
,2
,3
,4
]}

Yang, Dan ^{[1
,2
]}

Yang, Chengmin ^{[1
,2
,3
,4
]}

Sun, Hui ^{[1
,2
,3
,4
]}

Wei, Xia ^{[1
,2
,3
,4
]}

Sweeney, John A. ^{[3
,5
]}

Liang, Huilou ^{[6
]}

Zhang, Miaoqi ^{[6
]}

Gong, Qiyong ^{[1
,2
,3
,4
,7
]}

Lui, Su ^{[1
,2
,3
,4
,8
,9
]}

机构：

[1] Sichuan Univ, West China Hosp, Dept Radiol, Chengdu, Peoples R China

[2] Sichuan Univ, West China Hosp, Funct & Mol Imaging Key Lab Sichuan Prov, Chengdu, Peoples R China

[3] Sichuan Univ, West China Hosp, Huaxi MR Res Ctr HMRRC, Chengdu, Peoples R China

[4] Chinese Acad Med Sci, Res Unit Psychoradiol, Chengdu, Peoples R China

[5] Univ Cincinnati, Coll Med, Dept Psychiat & Behav Neurosci, Cincinnati, OH USA

[6] GE Healthcare, MR Res, Beijing, Peoples R China

[7] Sichuan Univ, West China Xiamen Hosp, Dept Radiol, Xiamen, Fujian, Peoples R China

[8] Sichuan Univ, West China Hosp, Dept Radiol, 37 Guoxue Xiang, Chengdu 610041, Peoples R China

[9] Sichuan Univ, West China Hosp, Funct & Mol Imaging Key Lab Sichuan Prov, 37 Guoxue Xiang, Chengdu 610041, Peoples R China

来源：

MEDCOMM | 2023年 / 4卷 / 04期

关键词：

diffusion tensor imaging; dorsolateral prefrontal cortex; fractional anisotropy; magnetic resonance imaging; mean diffusion; repetitive transcranial magnetic stimulation; MOTOR CORTEX; MRI; ROBUST; OPTIMIZATION; REGISTRATION; SENSITIVITY; FREQUENCY; ISCHEMIA; WHOLE; TMS;

D O I：

10.1002/mco2.335

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Repetitive transcranial magnetic stimulation (rTMS) is increasingly used to treat neuropsychiatric disorders. Inhibitory and excitatory regimens have been both adopted but the exact mechanism of action remains unclear, and investigating their differential effects on laminar diffusion profiles of neocortex may add important evidence. Twenty healthy participants were randomly assigned to receive a low-frequency/inhibitory or high-frequency/excitatory rTMS targeting the left dorsolateral prefrontal cortex (DLPFC). With the brand-new submillimeter diffusion tensor imaging of whole brain and specialized surface-based laminar analysis, fractional anisotropy (FA) and mean diffusion (MD) profiles of cortical layers at different cortical depths were characterized before/after rTMS. Inhibitory and excitatory rTMS both showed impacts on diffusion metrics of somatosensory, limbic, and sensory regions, but different patterns of changes were observed-increased FA with inhibitory rTMS, whereas decreased FA with excitatory rTMS. More importantly, laminar analysis indicated laminar specificity of changes in somatosensory regions during different rTMS patterns-inhibitory rTMS affected the superficial layers contralateral to the DLPFC, while excitatory rTMS led to changes in the intermediate/deep layers bilateral to the DLPFC. These findings provide novel insights into acute neurobiological effects on diffusion profiles of rTMS that may add critical evidence relevant to different protocols of rTMS on neocortex.

引用

页数：13

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