Recent progress in PLGA-based microneedle-mediated transdermal drug and vaccine delivery

被引：35
作者：
Malek-Khatabi, Atefeh [1 ,2 ]
Sadat Razavi, Malihe [4 ,6 ]
Abdollahi, Alyeh [1 ,2 ]
Rahimzadeghan, Milad [5 ]
Moammeri, Fatemeh [8 ]
Sheikhi, Mojgan [7 ]
Tavakoli, Mohamadreza [6 ]
Rad-Malekshahi, Mazda [1 ,2 ]
Faraji Rad, Zahra [3 ]
机构：
[1] Univ Tehran Med Sci, Dept Pharmaceut Biomat, Tehran, Iran
[2] Univ Tehran Med Sci, Fac Pharm, Med Biomat Res Ctr, Tehran, Iran
[3] Univ Southern Queensland, Sch Engn, Springfield, Qld 4300, Australia
[4] Mazandaran Univ Med Sci, Fac Pharm, Dept Pharmaceut, Sari, Iran
[5] Shahid Beheshti Univ Med Sci, Funct Neurosurg Res Ctr, Shohada Tajrish Comprehens Neurosurg Ctr Excellenc, Tehran, Iran
[6] Univ Tehran Med Sci, Fac Pharm, Nanotechnol Res Ctr, Tehran, Iran
[7] Univ Tehran Med Sci, Fac Pharm, Dept Drug & Food Control, Tehran, Iran
[8] Mashhad Univ Med Sci, Sch Paramed Sci, Dept Lab Sci, Mashhad, Iran
来源：
BIOMATERIALS SCIENCE | 2023年 / 11卷 / 16期
关键词：
DISSOLVING MICRONEEDLES; HOLLOW MICRONEEDLES; INTRADERMAL DELIVERY; NANOPARTICLES; ARRAYS; SKIN; ANTIGEN; RELEASE; SYSTEM; CHEMOTHERAPY;
D O I：
10.1039/d3bm00795b
中图分类号：
TB3 [工程材料学]; R318.08 [生物材料学];
学科分类号：
0805 ; 080501 ; 080502 ;
摘要：
Microneedles (MNs) have recently been found to have applications in drug, vitamin, protein and vaccine delivery. Polymeric MN arrays continue to attract increasing attention due to their capability to bypass the skin's stratum corneum (SC) barrier with minimal invasiveness. These carriers can achieve the targeted intradermal delivery of drugs and vaccines and improve their transdermal delivery level. As a nontoxic FDA-approved copolymer, polylactic glycolic acid (PLGA) has good biocompatibility and biodegradability. Currently, PLGA-based MNs have a noticeable tendency to be utilized as a delivery system. This study focuses on the most recent advances in PLGA-based MNs. Both PLGA nanoparticle-based MNs and PLGA matrix-based MNs, created for the delivery of vaccines, drugs, proteins and other therapeutic agents, are discussed. The paper also discusses the various types of MNs and their potential applications. Finally, the prospects and challenges of PLGA-based MNs are reviewed.
引用
收藏
页码：5390 / 5409
页数：20
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