MicroRNA-149 improves osteoarthritis via repression of VCAM-1 and inactivation of PI3K/AKT pathway

被引:16
作者
Jiang, Yongqin [1 ]
Zhang, Lei [1 ]
Tian, Huiyu [2 ]
机构
[1] Harbin Med Univ, Affiliated Hosp 2, Dept Orthoped, Harbin 150086, Heilongjiang, Peoples R China
[2] Second Hosp Heilongjiang Prov, Dept Phys Diag, Liaoyuan Rd 50, Harbin 150001, Heilongjiang, Peoples R China
关键词
Osteoarthritis; MicroRNA-149; PI3K; AKT pathway; Vascular cell adhesion molecule-1; INFLAMMATORY RESPONSE; CELL; PROLIFERATION; CHONDROCYTES; INHIBITION; APOPTOSIS; AUTOPHAGY;
D O I
10.1016/j.exger.2023.112103
中图分类号
R592 [老年病学]; C [社会科学总论];
学科分类号
03 ; 0303 ; 100203 ;
摘要
Objective: MicroRNAs (miRNAs) are key regulators in osteoarthritis (OA). While the role of miR-149 in OA has not been fully understood yet. This study investigated the mechanism in which miR-149 inhibited vascular cell adhesion molecule 1 (VCAM-1) via depressing PI3K/AKT pathway, thereby alleviating OA.Methods: A mouse OA model was constructed. The mice were injected with miR-149, VCAM-1- PI3K/AKT pathway-related sequences to figure their roles in OA. Inflammation and apoptosis were detected in the cartilage tissues of mice. MiR-149 and VCAM-1expression were detected. Results: Decreased miR-149 and enhanced VCAM-1 existed in cartilage tissues of patients with OA. Elevated miR149 or suppressed VCAM-1 limited inflammation and apoptosis in cartilage tissues of mice with OA, which was related to PI3K/AKT pathway inactivation.Conclusion: Our study provides evidence that up-regulated miR-149 alleviates OA via inhibition of VCAM-1 and PI3K/AKT pathway, which is helpful for OA treatment.
引用
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页数:9
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