Relapsing COVID-19 infection as a manifestation of Good syndrome: a case report and literature review

Good syndrome (GS) is a rare acquired immunodeficiency disease characterized by the presence of thy-moma with combined B and T cell immunodeficiency in adults. Recurrent bacterial infections, particu-larly sinopulmonary infections caused by encapsulated bacteria, remain the most common infective pre-sentation of GS; however, relapsing viral infections have also been reported, likely due to impaired T cell-mediated immunity. Relapsing COVID-19 infection, however, has not been previously reported as a manifestation of GS. We present two cases of relapsing COVID-19 infection in patients with GS; in one case, relapsing COVID-19 was the first manifestation of newly diagnosed GS. (c) 2022 The Author(s). Published by Elsevier Ltd on behalf of International Society for Infectious Diseases. This is an open access article under the CC BY-NC-ND license ( http://creativecommons.org/licenses/by-nc-nd/4.0/ )