Impact of dietary n-3 polyunsaturated fatty acid intake during the perinatal and post-weaning periods on the phospholipid and ganglioside composition of olfactory tissues

被引：2

作者：

Khoury, Spiro ^{[1
,2
]}

Soubeyre, Vanessa ^{[1
]}

Cabaret, Stephanie ^{[1
,2
]}

Gregoire, Stephane ^{[1
]}

Meziere, Esther ^{[1
,2
]}

Masson, Elodie ^{[1
]}

Grosmaitre, Xavier ^{[1
]}

Bretillon, Lionel ^{[1
]}

Berdeaux, Olivier ^{[1
,2
]}

Acar, Niyazi ^{[1
]}

Le Bon, Anne Marie ^{[1
]}

机构：

[1] Univ Bourgogne Franche Comte, Inst Agro, Ctr Sci Gout & Alimentat, CNRS,INRAE, F-21000 Dijon, France

[2] INRAE, PROBE Res Infrastruct, ChemoSens Facil, F-21000 Dijon, France

来源：

PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS | 2023年 / 191卷

关键词：

Olfactory mucosa; Olfactory bulb; Polyunsaturated fatty acid; Phospholipid; Ganglioside; Mass spectrometry; MOLECULAR-SPECIES COMPOSITION; ALPHA-LINOLENIC ACID; DOCOSAHEXAENOIC ACID; DOCOSAPENTAENOIC ACID; RAT RETINA; BRAIN; PHOSPHATIDYLSERINE; DEFICIENCY; GLYCOSPHINGOLIPIDS; BIOSYNTHESIS;

D O I：

10.1016/j.plefa.2023.102556

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The olfactory mucosa (OM) and olfactory bulb (OB) are neuronal tissues that contribute to the early processing of olfactory information. They contain significant amounts of n-3 and n-6 polyunsaturated fatty acids (PUFAs), which are crucial for neuronal tissue development. In this study, we evaluated the impact of feeding mice diets that are either deficient in alpha-linolenic acid (ALA) or supplemented with n-3 long-chain PUFAs from gestation to adolescence on the phospholipid and ganglioside composition of these tissues. Both diets modified the levels of some phospholipid classes, notably the phosphatidylserine and phosphatidylethanolamine levels. In addition, the low-ALA diet enriched n-6 PUFAs in the main phospholipid classes of both tissues, while the diet supplemented with n-3 PUFAs enhanced the n-3 PUFA-containing phospholipid species level, mainly in OM. The diets also modulated the levels and profiles of several ganglioside classes in OM and OB. These modifications may have repercussions on the olfactory sensitivity.

引用

页数：12