Effects of Endocrine-Disrupting Heavy Metals on Human Health

被引：55
作者：
Liu, Dongling [1 ]
Shi, Qianhan [2 ]
Liu, Cuiqing [2 ]
Sun, Qinghua [2 ]
Zeng, Xiang [2 ]
机构：
[1] Zhejiang Chinese Med Univ, Sch Basic Med Sci, 548 Binwen Rd, Hangzhou 310053, Peoples R China
[2] Zhejiang Chinese Med Univ, Sch Publ Hlth, 548 Binwen Rd, Hangzhou 310053, Peoples R China
来源：
TOXICS | 2023年 / 11卷 / 04期
关键词：
endocrine disruption; heavy metals; elements; thyroid hormone; estrogen; health; THYROID DISRUPTION; CADMIUM EXPOSURE; BLOOD LEAD; TOXICITY; HORMONES; MECHANISMS; CHILDREN; OUTCOMES; MERCURY;
D O I：
10.3390/toxics11040322
中图分类号：
X [环境科学、安全科学];
学科分类号：
08 ; 0830 ;
摘要：
s Heavy metals play an important endocrine-disrupting role in the health consequences. However, the endocrine-disrupting mechanism of heavy metals is unclear. There are long-term and low-level metal/element exposure scenes for the human body in real life. Therefore, animal models exposed to high doses of heavy metals may not provide key information to elucidate the underlying pathogeny of human diseases. This review collects current knowledge regarding the endocrine-disrupting roles of heavy metals such as lead (Pb), cadmium (Cd), arsenic (As), mercury (Hg), nickel (Ni), copper (Cu), zinc (Zn), and manganese (Mn), summarizes the possible molecular mechanisms of these endocrine-disrupting chemicals (EDCs), and briefly evaluates their endocrine toxicity on animals and humans.
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页数：8
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