Nanomedicine: New Frontiers in Fighting Microbial Infections

被引:8
|
作者
Mehrabi, Mohammad Reza [1 ]
Soltani, Madjid [2 ,3 ,4 ,5 ]
Chiani, Mohsen [1 ]
Raahemifar, Kaamran [6 ,7 ,8 ]
Farhangi, Ali [1 ]
机构
[1] Pasteur Inst Iran, Dept NanoBiotechnol, Tehran 1316943551, Iran
[2] KN Toosi Univ Technol, Dept Mech Engn, Tehran 1996715433, Iran
[3] KN Toosi Univ Technol, Adv Bioengn Initiat Ctr, Multidisciplinary Int Complex, Tehran 1417614411, Iran
[4] Univ Waterloo, Ctr Biotechnol & Bioengn CBB, Waterloo, ON N2L 3G1, Canada
[5] Univ Waterloo, Dept Elect & Comp Engn, Waterloo, ON N2L 3G1, Canada
[6] Penn State Univ, Coll Informat Sci & Technol IST, Data Sci & Artificial Intelligence Program, State Coll, PA 16801 USA
[7] Univ Waterloo, Dept Chem Engn, 200 Univ Ave West, Waterloo, ON N2L 3G1, Canada
[8] Univ Waterloo, Fac Sci, Sch Optometry & Vis Sci, 200 Univ Ave West, Waterloo, ON N2L 3G1, Canada
关键词
microbial infection; nanomedicine; vaccine; diagnosis; therapy; FUNCTIONALIZED GOLD NANOPARTICLES; ZINC-OXIDE NANOPARTICLES; STAPHYLOCOCCUS-AUREUS; METHICILLIN-RESISTANT; PSEUDOMONAS-AERUGINOSA; ANTIMICROBIAL EFFICACY; PEPTIDE NANOPARTICLES; SILVER NANOPARTICLES; IMMUNE-RESPONSE; IN-VITRO;
D O I
10.3390/nano13030483
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Microbes have dominated life on Earth for the past two billion years, despite facing a variety of obstacles. In the 20th century, antibiotics and immunizations brought about these changes. Since then, microorganisms have acquired resistance, and various infectious diseases have been able to avoid being treated with traditionally developed vaccines. Antibiotic resistance and pathogenicity have surpassed antibiotic discovery in terms of importance over the course of the past few decades. These shifts have resulted in tremendous economic and health repercussions across the board for all socioeconomic levels; thus, we require ground-breaking innovations to effectively manage microbial infections and to provide long-term solutions. The pharmaceutical and biotechnology sectors have been radically altered as a result of nanomedicine, and this trend is now spreading to the antibacterial research community. Here, we examine the role that nanomedicine plays in the prevention of microbial infections, including topics such as diagnosis, antimicrobial therapy, pharmaceutical administration, and immunizations, as well as the opportunities and challenges that lie ahead.
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收藏
页数:27
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