Head-to-head comparison of [68Ga]Ga-P16-093 and 2-[18F]FDG PET/CT in patients with clear cell renal cell carcinoma: a pilot study

被引：20
作者：
Wang, Guochang [1 ]
Li, Linlin [1 ]
Wang, Jiarou [1 ]
Zang, Jie [2 ]
Chen, Jingci [3 ]
Xiao, Yu [3 ]
Fan, Xinrong [4 ]
Zhu, Lin [5 ]
Kung, Hank F. F. [6 ]
Zhu, Zhaohui [1 ]
机构：
[1] Chinese Acad Med Sci, Peking Union Med Coll Hosp, Peking Union Med Coll, Dept Nucl Med,State Key Lab Complex Severe & Rare, Beijing 100730, Peoples R China
[2] Fujian Med Univ, Affiliated Hosp 1, Dept Nucl Med, Fujian Prov Key Lab Precis Med Canc, Fuzhou 350005, Peoples R China
[3] Chinese Acad Med Sci, Peking Union Med Coll Hosp, Peking Union Med Coll, Dept Pathol, Beijing 100730, Peoples R China
[4] Chinese Acad Med Sci, Peking Union Med Coll Hosp, Peking Union Med Coll, Dept Urol, Beijing 100730, Peoples R China
[5] Beijing Normal Univ, Coll Chem, Key Lab Radiopharmaceut, Minist Educ, Beijing 100875, Peoples R China
[6] Univ Penn, Dept Radiol, Philadelphia, PA 19104 USA
来源：
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING | 2023年 / 50卷 / 05期
基金：
北京市自然科学基金; 中国国家自然科学基金;
关键词：
2-[F-18]FDG; Clear cell renal cell carcinoma; PET; CT; Ga-68]Ga-P16-093; MEMBRANE ANTIGEN-EXPRESSION; PSMA EXPRESSION; CANCER; BIODISTRIBUTION; TOMOGRAPHY; DOSIMETRY; LESIONS; LIGAND; CT;
D O I：
10.1007/s00259-022-06101-3
中图分类号：
R8 [特种医学]; R445 [影像诊断学];
学科分类号：
1002 ; 100207 ; 1009 ;
摘要：
Purpose:This pilot study was prospectively designed to evaluate and compare the diagnostic value of PET/CT using a PSMA-specific tracer [Ga-68]Ga-P16-093 and a glucose metabolism probe 2-[F-18]FDG in clear cell renal cell carcinoma (ccRCC) patients. Methods:Forty-two pathologically confirmed ccRCC patients were included. Within 1 week, each patient underwent [Ga-68]Ga-P16-093 and 2-[F-18]FDG PET/CT. In addition to visual analysis of tumor number, the standardized uptake value (SUV) was measured for semiquantitative comparison and correlation analysis. Results:For primary ccRCC patients, [Ga-68]Ga-P16-093 PET/CT demonstrated a significantly higher detection rate (19/22 vs. 13/22, P = 0.031) and higher tumor uptake (15.7 +/- 9.0 vs. 5.1 +/- 3.4, P < 0.001) than 2-[F-18]FDG PET/CT. In addition, the SUVmax of the primary tumor on [Ga-68]Ga-P16-093 and 2-[F-18]FDG PET/CT was significantly correlated with pT stage (for [Ga-68]Ga-P16-093, r = 0.550, P = 0.008; for 2-[F-18]FDG, r = 0.514, P = 0.014) and WHO/ISUP grade (for [Ga-68]Ga-P16-093, r = 0.566, P = 0.006; for 2-[F-18]FDG, r = 0.492, P = 0.020), respectively. For metastatic ccRCC patients, [Ga-68]Ga-P16-093 PET/CT also demonstrated a better detection rate (21/22 vs. 14/22, P = 0.008) and higher tumor uptake (11.0 +/- 6.4 vs. 4.4 +/- 2.7, P < 0.001) than 2-[F-18]FDG PET/CT. The SUVmax on [Ga-68]Ga-P16-093 PET/CT had a significant association with PSMA expression in primary ccRCC (r = 0.776, P < 0.001) and metastatic ccRCC (r = 0.626, P = 0.029). Conclusions:[Ga-68]Ga-P16-093 PET/CT demonstrates significantly better tumor detectability than 2-[F-18]FDG PET/CT for ccRCC patients.
引用
收藏
页码：1499 / 1509
页数：11
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