A new δ-valerolactone produced by marine Streptomyces sp. YIM 13591

被引:4
作者
Zhang, Bing [1 ]
Zhao, Yu-ying [1 ]
Huang, Zhi-pu [1 ]
Zhang, Ke-tao [1 ]
Xu, Xiao-rong [1 ]
Zhao, Qing [1 ]
Zhang, Xiao-mei [1 ]
机构
[1] Yunnan Univ Chinese Med, Coll Basic Med, Coll Chinese Mat Med, Kunming, Yunnan, Peoples R China
基金
中国国家自然科学基金;
关键词
Actinomycetes; delta-valerolactone; Streptomyces sp; antimicrobial activities; RING;
D O I
10.1080/14786419.2022.2030734
中图分类号
O69 [应用化学];
学科分类号
081704 ;
摘要
A new delta-valerolactone compound, named 8-hydroxy invictolide 2 (1), a new natural product 4-hydroxy-3,5-dimethyl-6-(pentan-2-yl) tetrahydro-2H-pyran-2-one (2) together with four known compounds cyclo (L-Pro-L-Tyr) (3), cyclo (D-Pro-L-Tyr) (4), acetyltryptophan methyl ester (5), 2-aminobenzoic acid (6) were isolated from marine Streptomyces sp. YIM 13591. Their structures were elucidated by NMR spectroscopic data, HRESIMS and specific rotation, and the absolute configurations of the stereo centre in lactone ring 1 and 2 were further confirmed by electronic circular dichroism (ECD) calculation. The antimicrobial effects of these compounds were evaluated by the paper diffusion method. [GRAPHICS] .
引用
收藏
页码:2144 / 2150
页数:7
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