Maternal varicella antibodies in children aged less than one year: Assessment of antibody decay

被引：2

作者：

Bolotin, Shelly ^{[1
,2
,3
,4
]}

Hughes, Stephanie L. ^{[1
]}

Savage, Rachel D. ^{[1
,2
]}

McLachlan, Elizabeth ^{[5
,6
]}

Severini, Alberto ^{[5
,6
]}

Arnold, Callum ^{[7
]}

Richardson, Susan ^{[8
]}

Crowcroft, Natasha S. ^{[2
,3
,4
,9
]}

Deek, Shelley ^{[1
,2
]}

Halperin, Scott A. ^{[10
]}

Brown, Kevin A. ^{[1
,2
]}

Hatchette, Todd ^{[10
]}

Osman, Selma ^{[1
]}

Gubbay, Jonathan B. ^{[1
,4
,7
,11
]}

Science, Michelle ^{[1
,7
,11
,12
]}

机构：

[1] Publ Hlth Ontario, Toronto, ON, Canada

[2] Univ Toronto, Dalla Lana Sch Publ Hlth, Toronto, ON, Canada

[3] Univ Toronto, Ctr Vaccine Preventable Dis, Toronto, ON, Canada

[4] Univ Toronto, Dept Lab Med & Pathobiol, Toronto, ON, Canada

[5] Publ Hlth Agcy Canada, Natl Microbiol Lab, Ottawa, ON, Canada

[6] Univ Manitoba, Dept Med Microbiol, Winnipeg, MB, Canada

[7] Hosp Sick Children, Div Infect Dis, Toronto, ON, Canada

[8] Hosp Sick Children, Div Microbiol, Toronto, ON, Canada

[9] World Hlth Org, Dept Immunizat Vaccines & Biol, Geneva, Switzerland

[10] Dalhousie Univ, Canadian Ctr Vaccinol CCfV, IWK Hlth Ctr, Nova Scotia Hlth NSH, Halifax, NS, Canada

[11] Univ Toronto, Dept Paediat, Toronto, ON, Canada

[12] Hosp Sick Children, Dept Paediat, Toronto, ON, Canada

来源：

PLOS ONE | 2023年 / 18卷 / 11期

关键词：

RESOLVED FLUORESCENCE IMMUNOASSAY; ZOSTER-VIRUS; VACCINATION; CARE; IMMUNITY; RUBELLA; PRE; SEROEPIDEMIOLOGY; IMMUNOGENICITY; PERSISTENCE;

D O I：

10.1371/journal.pone.0287765

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Objectives To investigate maternal antibody levels to varicella in infants <12 months of age in Ontario, Canada. Study design In this study, we included specimens from infants <12 months of age, born at >= 37 weeks gestational age, who had sera collected at The Hospital for Sick Children (Toronto, Canada) between 2014-2016. We tested sera using a glycoprotein-based enzyme-linked immunosorbent assay (gpELISA). We measured varicella susceptibility (antibody concentration <150mIU/mL) and mean varicella antibody concentration, and assessed the probability of susceptibility and concentration between one and 11 months of age using multivariable logistic regression and Poisson regression. Results We found that 32% of 196 included specimens represented infants susceptible to varicella at one month of age, increasing to nearly 80% at three months of age. At six months of age, all infants were susceptible to varicella and the predicted mean varicella antibody concentration declined to 62 mIU/mL (95% confidence interval 40, 84), well below the threshold of protection. Conclusions We found that varicella maternal antibody levels wane rapidly in infants, leaving most infants susceptible by four months of age. Our findings have implications for the timing of first dose of varicella-containing vaccine, infection control measures, and infant post-exposure prophylaxis recommendations.

引用

页数：11

共 39 条

[1]

[Anonymous], 2010, CCDR

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