Customised 3D-Printed Surgical Guide for Breast-Conserving Surgery after Neoadjuvant Chemotherapy and Its Clinical Application

被引：2

作者：

Luo, Jie ^{[1
]}

Chen, Feng ^{[2
]}

Cao, Hong ^{[1
]}

Zhu, Wei ^{[2
]}

Deng, Jian ^{[1
]}

Li, Dan ^{[1
]}

Li, Wei ^{[1
]}

Deng, Junjie ^{[1
]}

Zhong, Yangyan ^{[1
]}

Feng, Haigang ^{[1
]}

Li, Yilin ^{[1
]}

Gong, Xiongmeiyu ^{[1
]}

Zeng, Jutao ^{[1
]}

Chen, Jiaren ^{[1
]}

机构：

[1] Univ South China, Hosp 2, Clin Res Ctr Breast & Thyroid Dis Prevent Hunan Pr, Dept Breast & Thyroid Surg, Hengyang 421001, Peoples R China

[2] Hunan Univ, Coll Mech & Vehicle Engn, Natl Engn Res Ctr High Efficiency Grinding, Changsha 410082, Peoples R China

来源：

BIOENGINEERING-BASEL | 2023年 / 10卷 / 11期

关键词：

breast cancer; surgery guide; 3D printing; neoadjuvant chemotherapy; preoperative planning; breast-conserving surgery; biomedical devices;

D O I：

10.3390/bioengineering10111296

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

For patients eligible to undergo breast-conserving surgery (BCS) after neoadjuvant chemotherapy, accurate preoperative localisation of tumours is vital to ensure adequate tumour resection that can reduce recurrence probability effectively. For this reason, we have developed a 3D-printed personalised breast surgery guide (BSG) assisted with supine magnetic resonance imaging (MRI) and image 3D reconstruction technology, capable of mapping the tumour area identified on MRI onto the breast directly using dual positioning based on the manubrium and nipple. In addition, the BSG allows the colour dye to be injected into the breast to mark the tumour region to be removed, yielding more accurate intraoperative resection and satisfactory cosmetic outcomes. The device has been applied to 14 patients from January 2018 to July 2023, with two positive margins revealed by the intraoperative biopsy. This study showed that the BSG-based method could facilitate precise tumour resection of BCS by accurately localising tumour extent and margin, promoting the clinical efficacy in patients with breast cancer as well as simplifying the surgical process.

引用

页数：13

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