Loss of ficolin-3 expression is associated with poor prognosis in patients with hepatocellular carcinoma

被引：5

作者：

Chen, Chia-Chi ^{[1
,2
,3
,4
]}

Yu, Teng-Hung ^{[5
,6
]}

Wu, Cheng-Ching ^{[5
,6
,7
]}

Hung, Wei-Chin ^{[5
,6
]}

Lee, Thung-Lip ^{[5
,8
]}

Tang, Wei-Hua ^{[9
,10
]}

Tsai, I-Ting ^{[6
]}

Chung, Fu-Mei ^{[5
]}

Lee, Yau-Jiunn

Hsu, Chia-Chang ^{[2
,11
]}

机构：

[1] I Shou Univ, E Da Hosp, Dept Pathol, Kaohsiung 82445, Taiwan

[2] I Shou Univ, Coll Med, Sch Chinese Med Post Baccalaureate, Kaohsiung 82445, Taiwan

[3] I Shou Univ, Dept Phys Therapy, Kaohsiung 82445, Taiwan

[4] I Shou Univ, Dept Occupat therapy, Kaohsiung 82445, Taiwan

[5] I Shou Univ, E Da Hosp, Dept Internal Med, Div Cardiol, Kaohsiung 82445, Taiwan

[6] I Shou Univ, Coll Med, Sch Med, Kaohsiung 82445, Taiwan

[7] I Shou Univ, E Da Canc Hosp, Dept Internal Med, Div Cardiol, Kaohsiung 82445, Taiwan

[8] I Shou Univ, Coll Med, Sch Med Int Students, Kaohsiung 82445, Taiwan

[9] Taipei Vet Gen Hosp, Dept Internal Med, Div Cardiol, Yuli Branch, Hualien 98142, Taiwan

[10] Natl Yang Ming Chiao Tung Univ, Fac Med, Sch Med, Taipei 112304, Taiwan

[11] I Shou Univ, E Da Hosp, 1 Yi-Da Rd,Jiau Shu Village, Kaohsiung 82445, Taiwan

来源：

INTERNATIONAL JOURNAL OF MEDICAL SCIENCES | 2023年 / 20卷 / 08期

关键词：

Hepatocellular carcinoma; ficolin-3; overall survival; immunohistochemistry; CANDIDATE BIOMARKERS; COMPLEMENT; IDENTIFICATION; PATHWAY; GENES; SERUM;

D O I：

10.7150/ijms.84729

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background: Ficolin-3 (FCN3) is a well-known circulating pattern recognition molecule which plays a role in host immune responses to cancer via activation of the lectin complement pathway. Nevertheless, the clinical significance of FCN3 in patients with hepatocellular carcinoma (HCC) is unclear.Methods: Eighty-seven HCC patients who received hepatectomy at our hospital were included. Immunohistochemical staining was used to assess the FCN3 expression in both tumorous and non-tumorous tissues from the patients, who were classified into high and low expression groups. Differences in clinicopathological characteristics between the two groups were then analyzed.Results: Survival was significantly associated with FCN3 immunohistochemical score (p for trend = 0.048). Kaplan-Meier analysis revealed a higher overall survival rate in the patients with a high FCN3 expression than in those with a low FCN3 expression (p=0.031). A high FCN3 expression in tumor tissue was independently associated with better overall survival (p=0.042). However, multivariate analysis showed that FCN3 expression was not an independent risk factor for overall survival.Conclusion: Our findings suggest that FCN3 is significantly related to the prognosis of HCC. FCN3 may be a prognostic marker in patients with HCC.

引用

页码：1091 / 1096

页数：6

共 31 条

[31] FCN2 inhibits epithelial-mesenchymal transition-induced metastasis of hepatocellular carcinoma via TGF-β/Smad signaling [J].

Yang, Guangchao ;

Liang, Yingjian ;

Zheng, Tongsen ;

Song, Ruipeng ;

Wang, Jiabei ;

Shi, Huawen ;

Sun, Boshi ;

Xie, Changming ;

Li, Yuejin ;

Han, Jihua ;

Pan, Shangha ;

Lan, Yaliang ;

Liu, Xirui ;

Zhu, Mingxi ;

Wang, Yan ;

Liu, Lianxin .

CANCER LETTERS, 2016, 378 (02) :80-86

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