Current progression in application of extracellular vesicles in central nervous system diseases

被引：5
|
作者：
Zhang, Xiang-Min [1 ,2 ]
Huang, Jie [1 ,2 ]
Ni, Xiao-Ying [1 ,2 ]
Zhu, Hui-Ru [1 ,2 ]
Huang, Zhong-Xin [1 ,2 ]
Ding, Shuang [1 ,2 ]
Yang, Xin-Yi [1 ,2 ]
Tan, Yan-Di [3 ]
Chen, Jian-Fu [4 ]
Cai, Jin-Hua [1 ]
机构：
[1] Chongqing Med Univ, Childrens Hosp, Natl Clin Res Ctr Child Hlth & Disorders, Dept Radiol,Minist Educ,Key Lab Child Dev & Disord, 136 Zhongshan Second Rd, Chongqing 400014, Peoples R China
[2] Chongqing Engn Res Ctr Stem Cell Therapy, 136 Zhongshan Second Rd, Chongqing 400014, Peoples R China
[3] Chongqing Med Univ, Affiliated Hosp 3, Dept Urol, 1 Shuanghu Branch Rd, Chongqing 401120, Peoples R China
[4] Second Peoples Hosp Yunnan Prov, Dept Ultrasound, 176 Qingnian Rd, Kunming 650021, Peoples R China
来源：
EUROPEAN JOURNAL OF MEDICAL RESEARCH | 2024年 / 29卷 / 01期
关键词：
Extracellular vesicles; Central nervous system diseases; Image; Molecular therapy; EXOSOME-MEDIATED DELIVERY; CELL-DERIVED EXOSOMES; FREE CLICK CHEMISTRY; IN-VIVO; STEM-CELLS; HUNTINGTONS-DISEASE; ALPHA-SYNUCLEIN; TARGETED DELIVERY; LABELED EXOSOMES; INSULIN-RECEPTOR;
D O I：
10.1186/s40001-023-01606-5
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Early diagnosis and pharmacological treatment of central nervous system (CNS) diseases has been a long-standing challenge for clinical research due to the presence of the blood-brain barrier. Specific proteins and RNAs in brain-derived extracellular vesicles (EVs) usually reflect the corresponding state of brain disease, and therefore, EVs can be used as diagnostic biomarkers for CNS diseases. In addition, EVs can be engineered and fused to target cells for delivery of cargo, demonstrating the great potential of EVs as a nanocarrier platform. We review the progress of EVs as markers and drug carriers in the diagnosis and treatment of neurological diseases. The main areas include visual imaging, biomarker diagnosis and drug loading therapy for different types of CNS diseases. It is hoped that increased knowledge of EVs will facilitate their clinical translation in CNS diseases.
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页数：14
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