GNRH2 Polymorphism in Men With Prostate Cancer Treated With Androgen Deprivation Therapy

被引：2

作者：

Sissung, Tristan M. ^{[1
]}

Lochrin, Sarah ^{[1
]}

Liu, Tyler ^{[1
]}

Schmidt, Keith ^{[1
]}

Strope, Jonathan ^{[2
]}

Risdon, Emily ^{[2
]}

Choo-Wosoba, Hyoyoung ^{[3
]}

Venzon, David J. ^{[3
]}

Lassoued, Wiem ^{[4
]}

Sater, Houssein A. ^{[4
]}

Walter-Rodriguez, Beatriz ^{[4
]}

Price, Douglas K. ^{[2
]}

Figg, William D. ^{[1
,2
,4
,5
]}

机构：

[1] NCI, Clim Pharmacol Program, Bethesda, MD USA

[2] NCI, Mol Pharmacol Sect, Bethesda, MD USA

[3] NCI, Biostat & Data Management Sect, Bethesda, MD USA

[4] NCI, Ctr Canc Res, Genitourinary Malignancies Branch, Bethesda, MD USA

[5] 9000 Rockville Pike,Bldg 10,Room 5A03, Bethesda, MD 20892 USA

来源：

ANTICANCER RESEARCH | 2023年 / 43卷 / 09期

关键词：

GNRH2; prostate cancer; androgen deprivation therapy; survival; GONADOTROPIN-RELEASING-HORMONE; SERUM TESTOSTERONE; GNRH; RECEPTOR; SURVIVAL;

D O I：

10.21873/anticanres.16590

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background/Aim: Gonadotropin-releasing hormone 2 (GNRH2) is a poorly-studied peptide hormone that is widely distributed in the central nervous system and expressed in peripheral tissues of mammals. The nonsynonymous rs6051545 variant in GNRH2 (A16V) has been linked to higher serum testosterone concentrations. This study investigated whether the A16V variant is associated with altered androgen-deprivation therapy (ADT) progression-free survival (PFS) and overall survival (OS). Patients and Methods: We examined the expression of GNRH2 in prostate tissue microarrays comprising normal tissue, prostatic hyperplasia, and prostate cancer using immunofluorescence. We also evaluated the GNRH2 genotype in 131 patients with prostate cancer who received ADT and compared PFS and OS between the variant and wild-type genotypes. Results: GNRH2 was detected in all prostate tissues, although expression did not vary with Gleason grade or disease stage (p=0.71). The GNRH2 A16V genotype was not associated with PFS or OS; however, univariate and multivariate analyses revealed Gleason score and definitive local therapy were each associated with PFS (p=0.0074), whereas age and Gleason score were associated with OS (p=0.0046). Conclusion: GNRH2 is expressed in normal, hyperplastic, and neoplastic prostate tissues; the A16V variant is not related to treatment outcome or survival.

引用

页码：4023 / 4030

页数：8

共 14 条

[1] Expression of GnRH type II is regulated by the androgen receptor in prostate cancer [J].