Emerging role of substance and energy metabolism associated with neuroendocrine regulation in tumor cells

被引:2
作者
Liu, Yingying [1 ,2 ,3 ,4 ]
Gu, Renjun [3 ,4 ]
Gao, Murong [5 ]
Wei, Yangwa [6 ]
Shi, Yu [7 ]
Wang, Xu [8 ]
Gu, Yihuang [9 ,10 ]
Gu, Xin [3 ,4 ]
Zhang, Hongru [3 ,4 ]
机构
[1] Tsinghua Univ, Inst Immunol, Beijing, Peoples R China
[2] Tsinghua Univ, Sch Med, Beijing, Peoples R China
[3] Nanjing Univ Chinese Med, Sch Chinese Med, Nanjing, Peoples R China
[4] Nanjing Univ Chinese Med, Sch Integrated Chinese & Western Med, Nanjing, Peoples R China
[5] Capital Med Univ, Beijing Rehabil Hosp, Beijing, Peoples R China
[6] Hainan Prov Peoples Hosp, Dept Hepatobiliary Surg, Haikou, Peoples R China
[7] Tongji Univ, Shanghai East Hosp, Sch Med, Shanghai, Peoples R China
[8] Fujian Med Univ, Sch Basic Med Sci, Fuzhou, Peoples R China
[9] Nanjing Univ Chinese Med, Sch Acupuncture & Tuina, Sch Regimen & Rehabil, Nanjing, Peoples R China
[10] Second Hosp Nanjing, Nanjing, Peoples R China
来源
FRONTIERS IN ENDOCRINOLOGY | 2023年 / 14卷
基金
中国国家自然科学基金;
关键词
substance; energy; metabolism; neuroendocrine regulation; tumor cells; GAMMA-AMINOBUTYRIC-ACID; CENTRAL NERVOUS-SYSTEM; NEUROPEPTIDE-Y; BETA-BLOCKERS; BETA(3)-ADRENERGIC RECEPTOR; OXIDATIVE STRESS; CANCER-CELLS; IN-VITRO; GLUTAMATE; SEROTONIN;
D O I
10.3389/fendo.2023.1126271
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Cancer is the second most common cause of mortality in the world. One of the unresolved difficult pathological mechanism issues in malignant tumors is the imbalance of substance and energy metabolism of tumor cells. Cells maintain life through energy metabolism, and normal cells provide energy through mitochondrial oxidative phosphorylation to generate ATP, while tumor cells demonstrate different energy metabolism. Neuroendocrine control is crucial for tumor cells' consumption of nutrients and energy. As a result, better combinatorial therapeutic approaches will be made possible by knowing the neuroendocrine regulating mechanism of how the neuroendocrine system can fuel cellular metabolism. Here, the basics of metabolic remodeling in tumor cells for nutrients and metabolites are presented, showing how the neuroendocrine system regulates substance and energy metabolic pathways to satisfy tumor cell proliferation and survival requirements. In this context, targeting neuroendocrine regulatory pathways in tumor cell metabolism can beneficially enhance or temper tumor cell metabolism and serve as promising alternatives to available treatments.
引用
收藏
页数:14
相关论文
共 153 条
[1]   Association of dopamine β-hydroxylase polymorphism with hypertension through interaction with fasting plasma glucose in Japanese [J].
Abe, M ;
Wu, ZH ;
Yamamoto, M ;
Jin, JJ ;
Tabara, Y ;
Mogi, M ;
Kohara, K ;
Miki, T ;
Nakura, J .
HYPERTENSION RESEARCH, 2005, 28 (03) :215-221
[2]   Are Beta Blockers New Potential Anticancer Agents? [J].
Akbar, Shahid ;
Alsharidah, Mansour Saleh .
ASIAN PACIFIC JOURNAL OF CANCER PREVENTION, 2014, 15 (22) :9567-9574
[3]   Neurogenesis in Colorectal Cancer Is a Marker of Aggressive Tumor Behavior and Poor Outcomes [J].
Albo, Daniel ;
Akay, Catherine L. ;
Marshall, Christy L. ;
Wilks, Jonathan A. ;
Verstovsek, Gordana ;
Liu, Hao ;
Agarwal, Neeti ;
Berger, David H. ;
Ayala, Gustavo E. .
CANCER, 2011, 117 (21) :4834-4845
[4]   ACTIVITY OF SINGLE NEURONS IN HYPOTHALAMIC FEEDING CENTERS - EFFECT OF GLUCOSE [J].
ANAND, BK ;
SINGH, B ;
DUA, S ;
SHARMA, KN ;
CHHINA, GS .
AMERICAN JOURNAL OF PHYSIOLOGY, 1964, 207 (05) :1146-+
[5]   Histone Serotonylation: Can the Brain Have "Happy'' Chromatin? [J].
Anastas, Jamie N. ;
Shi, Yang .
MOLECULAR CELL, 2019, 74 (03) :418-420
[6]  
[Anonymous], DROPPED
[7]   Opinion - The influence of bio-behavioural factors on tumour biology: pathways and mechanisms [J].
Antoni, MH ;
Lutgendorf, SK ;
Cole, SW ;
Dhabhar, FS ;
Sephton, SE ;
McDonald, PG ;
Stefanek, M ;
Sood, AK .
NATURE REVIEWS CANCER, 2006, 6 (03) :240-248
[8]   BETA(3)-ADRENOCEPTOR AND ATYPICAL BETA-ADRENOCEPTOR [J].
ARCH, JRS ;
KAUMANN, AJ .
MEDICINAL RESEARCH REVIEWS, 1993, 13 (06) :663-729
[9]  
Azuma H, 2003, CANCER RES, V63, P8090
[10]   Targeted therapy with propranolol and metronomic chemotherapy combination: sustained complete response of a relapsing metastatic angiosarcoma [J].
Banavali, Shripad ;
Pasquier, Eddy ;
Andre, Nicolas .
ECANCERMEDICALSCIENCE, 2015, 9