Saffron as a promising therapy for diabetes and Alzheimer's disease: mechanistic insights

被引：8

作者：

Sanaie, Sarvin ^{[1
]}

Nikanfar, Saba ^{[2
]}

Kalekhane, Zahra Yousefi ^{[3
,4
]}

Azizi-Zeinalhajlou, Akbar ^{[5
,6
]}

Sadigh-Eteghad, Saeed ^{[7
]}

Araj-Khodaei, Mostafa ^{[1
,8
]}

Ayati, Mohammad Hossein ^{[1
,9
]}

Andalib, Sasan ^{[10
]}

机构：

[1] Tabriz Univ Med Sci, Res Ctr Integrat Med Aging, Aging Res Inst, Tabriz, Iran

[2] Tabriz Univ Med Sci, Fac Med, Dept Biochem & Clin Labs, Tabriz, Iran

[3] Tabriz Univ Med Sci, Res Ctr Psychiat & Behav Sci, Aging Res Inst, Tabriz, Iran

[4] Univ Tabriz, Fac Educ Sci & Psychol, Dept Psychol, Tabriz, Iran

[5] Tabriz Univ Med Sci, Aging Res Inst, Student Res Comm, Tabriz, Iran

[6] Tabriz Univ Med Sci, Phys Med & Rehabil Res Ctr, Aging Res Inst, Tabriz, Iran

[7] Tabriz Univ Med Sci, Neurosci Res Ctr, Tabriz, Iran

[8] Tabriz Univ Med Sci, Sch Tradit Med, Dept Persian Med, Tabriz, Iran

[9] Univ Tehran Med Sci, Sch Persian Med, Dept Tradit Med, Tehran, Iran

[10] Univ Southern Denmark, Fac Hlth Sci, Odense Univ Hosp, Dept Clin Res,Res Unit Clin Physiol & Nucl Med, Odense, Denmark

来源：

METABOLIC BRAIN DISEASE | 2023年 / 38卷 / 01期

关键词：

Alzheimer's disease; Diabetes; Herbal medicine; Saffron; CROCUS-SATIVUS-L; GLYCATION END-PRODUCTS; INDUCED COGNITIVE DEFICITS; BLOOD-BRAIN-BARRIER; INDUCED CELL-DEATH; AMYLOID-BETA; OXIDATIVE STRESS; MEMORY IMPAIRMENTS; AQUEOUS EXTRACT; DOUBLE-BLIND;

D O I：

10.1007/s11011-022-01059-5

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The prevalence of both Alzheimer's disease (AD) and diabetes mellitus is increasing with the societies' aging and has become an essential social concern worldwide. Accumulation of amyloid plaques and neurofibrillary tangles (NFTs) of tau proteins in the brain are hallmarks of AD. Diabetes is an underlying risk factor for AD. Insulin resistance has been proposed to be involved in amyloid-beta (A beta) aggregation in the brain. It seems that diabetic conditions can result in AD pathology by setting off a cascade of processes, including inflammation, mitochondrial dysfunction, and ROS and advanced glycation end products (AGEs) synthesis. Due to the several side effects of chemical drugs and their high cost, using herbal medicine has recently attracted attention for the treatment of diabetes and AD. Saffron and its active ingredients have been used for its anti-inflammatory, anti-oxidant, anti-diabetic, and anti-AD properties. Therefore, in the present review paper, we take account of the clinical, in vivo and in vitro evidence regarding the anti-diabetic and anti-AD effects of saffron and discuss the preventive or postponing properties of saffron or its components on AD development via its anti-diabetic effects.

引用

页码：137 / 162

页数：26

共 205 条

[1] The effect of crocin (the main active saffron constituent) on the cognitive functions, craving, and withdrawal syndrome in opioid patients under methadone maintenance treatment [J].