Role of Interleukin-22 in ulcerative colitis

被引：15

作者：

Zhao, Nan ^{[1
]}

Liu, Chuanguo ^{[2
]}

Li, Ning ^{[1
]}

Zhou, Shuang ^{[1
]}

Guo, Yuting ^{[1
]}

Yang, Shihua ^{[3
]}

Liu, Huimin ^{[1
]}

机构：

[1] Shandong Univ Tradit Chinese Med, Coll Tradit Chinese Med, Jinan 250355, Peoples R China

[2] Shandong Univ Tradit Chinese Med, Expt Ctr, Jinan 250355, Peoples R China

[3] Fifth Peoples Hosp Jinan, Dept Oncol, Jinan 250022, Peoples R China

来源：

BIOMEDICINE & PHARMACOTHERAPY | 2023年 / 159卷

基金：

中国国家自然科学基金;

关键词：

IL-22; Ulcerative Colitis; IL-22BP; STAT3; INNATE LYMPHOID-CELLS; CHAIN FATTY-ACIDS; T-CELL; FAECALIBACTERIUM-PRAUSNITZII; IL-22; PRODUCTION; INTESTINAL MICROBIOTA; BINDING-PROTEIN; RETINOIC ACID; HUMAN GUT; INFLAMMATION;

D O I：

10.1016/j.biopha.2023.114273

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Ulcerative Colitis (UC) is a chronic disease, in the progression of which an immune overreaction may play an important role. IL-22 is a member of the IL-10 superfamily of cytokines and is pleiotropic in immune regulation and inflammatory responses. IL-22 can produce protective effects, promote wound healing and tissue regener-ation, while it can also induce inflammatory reactions when it is chronically overexpressed. Extensive literatures reported that IL-22 played an essential role in the pathogenic development of UC. IL-22 participates in the whole disease process of UC involving signaling pathways, gene expression regulation, and intestinal flora imbalance, making IL-22 a possible candidate for the treatment of UC. In this paper, the latest knowledge to further elucidate the role of IL-22 in UC was summarized and analyzed.

引用

页数：9

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