Oxalate:from physiology to pathology

被引：2

作者：

Grocholski, Christophe ^{[1
,2
]}

Dubourg, Laurence Derain ^{[2
,3
,4
,5
]}

Guebre-Egziabher, Fitsum ^{[2
,4
,6
]}

Acquaviva-Bourdain, Cecile ^{[7
]}

Abid, Nadia ^{[8
]}

Bacchetta, Justine ^{[3
,4
,9
,10
]}

Chambrier, Cecile ^{[11
]}

Lemoine, Sandrine ^{[2
,3
,4
,6
]}

机构：

[1] Ctr Hosp Fleyriat, Serv Nephrol Dialyse, 900 Route Paris, F-01012 Bourg En Bresse, France

[2] Hosp Civils Lyon, Hop Edouard Herriot, Serv Nephrol Dialyse Hypertens & Explorat Fonct R, 5 Pl Arsonval, F-69003 Lyon, France

[3] Hop Femme Mere Enfant, Ctr Reference Malad Renales Rares & Phosphocalc N, 32 Ave Doyen Jean Lepine, F-69500 Bron, France

[4] Univ Claude Bernard, Fac Med Lyon Est, Lyon 1, 43,Bd 11 Novembre 1918, F-69100 Villeurbanne, France

[5] CNRS, Lab Biol Tissulaire & Ingn Therapeut, UMR 5305, 7 Passage Vercors, F-69367 Lyon 7, France

[6] Grp Hosp Est, Inserm CarMeN U1060, 59 Bd Pinel, F-69500 Bron, France

[7] Hosp Civils Lyon, Grp Hosp Est, Serv Biochim & Biol Mol, Unite Malad Hereditaires Metab, 59 Bd Pinel, F-69677 Bron, France

[8] Hosp Civils Lyon, Serv Urol & Chirurg Transplantat, Hop Edouard Herriot, 5 Pl Arsonval, F-69003 Lyon, France

[9] Hosp Civils Lyon, Serv Nephrol Rhumatol Dermatol Pediat, Hop Femme Mere Enfant, 59 Bd Pinel, F-69500 Bron, France

[10] INSERM, U1033, Prevent Malad Osseuses, 7 Rue Guillaume Paradin, F-69372 Lyon 08, France

[11] Hosp Civils Lyon, Serv Nutr Clin Intens, Hop Lyon Sud, 165 Chemin Grand Revoyet, F-69495 Pierre Benite, France

来源：

NEPHROLOGIE & THERAPEUTIQUE | 2023年 / 19卷 / 03期

关键词：

oxalate; hyperoxaluria; enteric hyperoxaluria; physiology; PRIMARY HYPEROXALURIA TYPE-1; CALCIUM-OXALATE; URINARY OXALATE; DIETARY OXALATE; ASCORBIC-ACID; OXALOBACTER-FORMIGENES; DEGRADING BACTERIA; SECONDARY OXALOSIS; METABOLISM; ABSORPTION;

D O I：

10.1684/ndt.2023.10

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Hyperoxaluria is defined by an increase of urinary oxalate, leading to kidney stones, nephrocalcinosis and/or chronic kidney disease. There are different diseases related to hyperoxaluria: (1) kidney stones, 50% of them being explained by intermittent hyperoxaluria, secondary to dietary mistakes such as low hydration, excess of oxalate consumption and/or low calcium consumption; (2) primary hyperoxaluria, a genetic orphan disease inducing a massive production of oxalate by the liver, leading to increased plasma oxalate increase and saturation, and further systemic oxalosis with oxalate deposition, nephrocalcinosis and ultimately kidney failure, the management of this disease being currently dramatically modified by the onset of new therapeutic tools such as RNA interference; and (3) enteric hyperoxaluria, resulting from increased intestinal oxalate absorption because of intestinal malabsorption (short bowel syndrome, bariatric surgery, exocrine pancreatic insufficiency, etc.). Diagnosis and therapeutic management of these diseases require a full understanding of oxalate physiology that we detail in this review.

引用

页码：201 / 214

页数：14

共 100 条

[11]

Chen ZQ, 2003, CHINESE MED J-PEKING, V116, P1749

[12] Primary hyperoxaluria Type 1: indications for screening and guidance for diagnosis and treatment [J].