Transcriptomic Profiling Of Sars-cov-2 Spike Protein S1 Subunit Mediated Changes In Human Vascular -pericytes, -endothelial Cells (ECs), -smooth Muscle Cells And Lymphatic ECs: Evidence For Differential Gene Regulation

被引:0
|
作者
Dubey, Raghvendra K.
Azzarito, Giovanna
Leeners, Brigitte
Rosselli, Marinella
机构
关键词
Vascular disease; COVID-19; Inflammation;
D O I
10.1161/hyp.80.suppl_1.P310
中图分类号
R6 [外科学];
学科分类号
1002 ; 100210 ;
摘要
AP310
引用
收藏
页数:2
相关论文
共 12 条
  • [1] Cell-Free Hemoglobin Does Not Attenuate the Effects of SARS-CoV-2 Spike Protein S1 Subunit in Pulmonary Endothelial Cells
    Jana, Sirsendu
    Heaven, Michael R.
    Alayash, Abdu, I
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2021, 22 (16)
  • [2] Endothelial Cell Activation by SARS-CoV-2 Spike S1 Protein: A Crosstalk between Endothelium and Innate Immune Cells
    Rotoli, Bianca Maria
    Barilli, Amelia
    Visigalli, Rossana
    Ferrari, Francesca
    Dall'Asta, Valeria
    BIOMEDICINES, 2021, 9 (09)
  • [3] SARS-CoV-2 spike S1 subunit protein-mediated increase of beta-secretase 1 (BACE1) impairs human brain vessel cells
    Choi, Ji-Young
    Park, Jung Hyun
    Jo, Chulman
    Kim, Kyung-Chang
    Koh, Young Ho
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2022, 626 : 66 - 71
  • [4] The SARS-CoV-2 spike S1 protein induces global proteomic changes in ATII-like rat L2 cells that are attenuated by hyaluronan
    Mobley, James A.
    Molyvdas, Adam
    Kojima, Kyoko
    Ahmad, Israr
    Jilling, Tamas
    Li, Jian-Liang
    Garantziotis, Stavros
    Matalon, Sadis
    AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, 2023, 324 (04) : L413 - L432
  • [5] The SARS-CoV-2 S1 Spike Protein Promotes MAPK and NF-kB Activation in Human Lung Cells and Inflammatory Cytokine Production in Human Lung and Intestinal Epithelial Cells
    Forsyth, Christopher B.
    Zhang, Lijuan
    Bhushan, Abhinav
    Swanson, Barbara
    Zhang, Li
    Mamede, Joao, I
    Voigt, Robin M.
    Shaikh, Maliha
    Engen, Phillip A.
    Keshavarzian, Ali
    MICROORGANISMS, 2022, 10 (10)
  • [6] Induction of Exaggerated Cytokine Production in Human Peripheral Blood Mononuclear Cells by a Recombinant SARS-CoV-2 Spike Glycoprotein S1 and Its Inhibition by Dexamethasone
    Olajide, Olumayokun A.
    Iwuanyanwu, Victoria U.
    Lepiarz-Raba, Izabela
    Al-Hindawi, Alaa A.
    INFLAMMATION, 2021, 44 (05) : 1865 - 1877
  • [7] SARS-CoV-2 spike protein S1 subunit induces pro-inflammatory responses via toll-like receptor 4 signaling in murine and human macrophages
    Shirato, Ken
    Kizaki, Takako
    HELIYON, 2021, 7 (02)
  • [8] The S1 Subunit of the SARS-CoV-2 Spike Protein Activates Human Monocytes to Produce Cytokines Linked to COVID-19: Relevance to Galectin-3
    Schroeder, John T.
    Bieneman, Anja P.
    FRONTIERS IN IMMUNOLOGY, 2022, 13
  • [9] Differential Mitochondrial, Oxidative Stress and Inflammatory Responses to SARS-CoV-2 Spike Protein Receptor Binding Domain in Human Lung Microvascular, Coronary Artery Endothelial and Bronchial Epithelial Cells
    Kulkoviene, Gabriele
    Narauskaite, Deimante
    Tunaityte, Agile
    Volkeviciute, Augusta
    Balion, Zbigniev
    Kutakh, Olena
    Gecys, Dovydas
    Kairyte, Milda
    Uldukyte, Martyna
    Stankevicius, Edgaras
    Jekabsone, Aiste
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2024, 25 (06)
  • [10] Induction of Exaggerated Cytokine Production in Human Peripheral Blood Mononuclear Cells by a Recombinant SARS-CoV-2 Spike Glycoprotein S1 and Its Inhibition by Dexamethasone
    Olumayokun A. Olajide
    Victoria U. Iwuanyanwu
    Izabela Lepiarz-Raba
    Alaa A. Al-Hindawi
    Inflammation, 2021, 44 : 1865 - 1877