Ribonucleoside Hydrolases-Structure, Functions, Physiological Role and Practical Uses

被引：3
|
作者：
Shaposhnikov, Leonid A. [1 ,2 ]
Savin, Svyatoslav S. [1 ,2 ]
Tishkov, Vladimir I. [1 ,2 ]
Pometun, Anastasia A. [1 ,2 ]
机构：
[1] Russian Acad Sci, Bach Inst Biochem, Fed Res Ctr Fundamentals Biotechnol, Moscow 119071, Russia
[2] Lomonosov Moscow State Univ, Chem Fac, Dept Chem Enzymol, Moscow 119991, Russia
来源：
BIOMOLECULES | 2023年 / 13卷 / 09期
基金：
俄罗斯科学基金会;
关键词：
nucleoside hydrolases; crystal structure; catalysis mechanism; enzyme kinetics; cancer drug design; ARCHAEON SULFOLOBUS-SOLFATARICUS; URIDINE NUCLEOSIDE HYDROLASE; CATABOLIC ENZYME-ACTIVITIES; TRANSITION-STATE; BIOCHEMICAL-CHARACTERIZATION; SUBSTRATE-SPECIFICITY; PYRIMIDINE RIBONUCLEOSIDES; PSEUDOMONAS-AERUGINOSA; PURINE RIBONUCLEOSIDES; CONFORMATIONAL-CHANGES;
D O I：
10.3390/biom13091375
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Ribonucleoside hydrolases are enzymes that catalyze the cleavage of ribonucleosides to nitrogenous bases and ribose. These enzymes are found in many organisms: bacteria, archaea, protozoa, metazoans, yeasts, fungi and plants. Despite the simple reaction catalyzed by these enzymes, their physiological role in most organisms remains unclear. In this review, we compare the structure, kinetic parameters, physiological role, and potential applications of different types of ribonucleoside hydrolases discovered and isolated from different organisms.
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页数：25
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