Vitamin D Receptor Activation Targets ROS-Mediated Crosstalk Between Autophagy and Apoptosis in Hepatocytes in Cholestasic Mice

被引：13
|
作者：
Zheng, Zhijian [1 ]
Xie, Jing [2 ]
Ma, Liman [2 ]
Hao, Zhiqing [3 ]
Zhang, Weiwei [3 ]
Li, Lihua [1 ]
机构：
[1] Taizhou Univ, Affliated Wenling Peoples Hosp 1, Dept Gen Surg, 21 Mingyuan Rd, Taizhou 317500, Zhejiang, Peoples R China
[2] Taizhou Univ, Sch Med, Dept Cell Biol, Taizhou, Zhejiang, Peoples R China
[3] Shenyang Med Coll, Sch Basic Med, Dept Pathophysiol, Shenyang, Liaoning, Peoples R China
来源：
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY | 2023年 / 15卷 / 04期
基金：
中国国家自然科学基金;
关键词：
Vitamin D-Receptor Activation; Autophagy; Apoptosis; ROS Generation; ERK/p38MAPK Pathway; LIVER-INJURY; CANCER CELLS; PROTECTS; FIBROSIS; DEATH; DISRUPTION; SENESCENCE; PATHWAY; ATG5;
D O I：
10.1016/j.jcmgh.2022.10.011
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
Vitamin D receptor (VDR) agonist paricalcitol up-regulates VDR expression in hepatocytes in mice liver. Treatment with paricalcitol improves bile duct-ligated mice liver injury by reducing hepatocyte apoptosis. Up-regulation of VDR-inhibited apoptosis is autophagy-dependent and via the inhibiting reactive oxygen species generation by extracel-lular signal-regulated kinase/p38 mitogen-activated protein kinase pathway.
引用
收藏
页码：887 / 901
页数：15
相关论文
共 18 条
  • [1] Targeting ROS-Mediated Crosstalk Between Autophagy and Apoptosis in Cancer
    Gao, Lixia
    Loveless, Jenni
    Shay, Chloe
    Teng, Yong
    REVIEWS ON NEW DRUG TARGETS IN AGE-RELATED DISORDERS, 2020, 1260 : 1 - 12
  • [2] Activation of Autophagy Protects Against ROS-Mediated Mitochondria- Dependent Apoptosis in L-02 Hepatocytes Induced by Cr(VI)
    Xie, Ying
    Xiao, Fang
    Luo, Lei
    Zhong, Caigao
    CELLULAR PHYSIOLOGY AND BIOCHEMISTRY, 2014, 33 (03) : 705 - 716
  • [3] Imbalance of early-life vitamin D intake targets ROS-mediated crosstalk between mitochondrial dysfunction and differentiation potential of MSCs associated the later obesity
    Li, Ping
    Wang, Yang
    Liang, Yueqing
    Jiang, Xueyi
    Tang, Tiantian
    Fan, Xiuqin
    Wang, Rui
    Yang, Mengyi
    Liu, Yuanlin
    Qi, Kemin
    Zhang, Yi
    STEM CELL RESEARCH & THERAPY, 2024, 15 (01)
  • [4] The Antitumor Potential of Sicilian Grape Pomace Extract: A Balance between ROS-Mediated Autophagy and Apoptosis
    Affranchi, Federica
    Di Liberto, Diana
    Lauricella, Marianna
    D'Anneo, Antonella
    Calvaruso, Giuseppe
    Pratelli, Giovanni
    Carlisi, Daniela
    De Blasio, Anna
    Tesoriere, Luisa
    Giuliano, Michela
    Notaro, Antonietta
    Emanuele, Sonia
    BIOMOLECULES, 2024, 14 (09)
  • [5] Rhopaloic acid A induces apoptosis, autophagy and MAPK activation through ROS-mediated signaling in bladder cancer
    Hung, Shih-Ya
    Chen, Wu-Fu
    Lee, Yi-Chen
    Su, Jui-Hsin
    Juan, Yung-Shun
    Lin, In-Pin
    Zhang, Ya-Hui
    Chang, Ming-Kai
    Lin, Mei-Ying
    Chen, Chung-Yi
    Lee, Chien-Hsing
    PHYTOMEDICINE, 2021, 92
  • [6] Alkannin induces cytotoxic autophagy and apoptosis by promoting ROS-mediated mitochondrial dysfunction and activation of JNK pathway
    Zheng, Qianwen
    Li, Qin
    Zhao, Gang
    Zhang, Jie
    Yuan, Hang
    Gong, Di
    Guo, Yafei
    Liu, Xinhua
    Li, Kai
    Lin, Ping
    BIOCHEMICAL PHARMACOLOGY, 2020, 180
  • [7] Isolinderalactone Induces Apoptosis, Autophagy, Cell Cycle Arrest and MAPK Activation through ROS-Mediated Signaling in Colorectal Cancer Cell Lines
    Chen, Jith-Shyan
    Chiu, Sheng-Chun
    Huang, Sung-Ying
    Chang, Shu-Fang
    Liao, Kuan-Fu
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2023, 24 (18)
  • [8] Vitamin D Receptor Activation Reduces Hepatic Inflammation via Enhancing Macrophage Autophagy in Cholestatic Mice
    Wen, Tianfu
    Xie, Jing
    Ma, Liman
    Hao, Zhiqing
    Zhang, Weiwei
    Wu, Tingyao
    Li, Lihua
    AMERICAN JOURNAL OF PATHOLOGY, 2024, 194 (03): : 369 - 383
  • [9] Vitamin D Receptor Activation Protects Against Myocardial Reperfusion Injury Through Inhibition of Apoptosis and Modulation of Autophagy
    Yao, Tianbao
    Ying, Xiaoying
    Zhao, Yichao
    Yuan, Ancai
    He, Qing
    Tong, Huan
    Ding, Song
    Liu, Junling
    Peng, Xu
    Gao, Erhe
    Pu, Jun
    He, Ben
    ANTIOXIDANTS & REDOX SIGNALING, 2015, 22 (08) : 633 - 650
  • [10] Epigallocatechin gallate (EGCG) restores 25-hydroxy vitamin D levels in rheumatoid arthritis patients by attenuating ROS-mediated activation of NF-KB
    Liu, Yuhong
    Xie, Yidun
    Liu, Mailing
    Yang, Junfeng
    TROPICAL JOURNAL OF PHARMACEUTICAL RESEARCH, 2021, 20 (07) : 1395 - 1402
12