Regulation of SUMOylation on RNA metabolism in cancers

被引:10
作者
Cao, Yingting [1 ]
Huang, Caihu [1 ]
Zhao, Xian [1 ]
Yu, Jianxiu [1 ]
机构
[1] Shanghai Jiao Tong Univ, Sch Med, Dept Biochem & Mol Cell Biol, Shanghai Key Lab Tumor Microenvironm & Inflammat, Shanghai, Peoples R China
基金
中国国家自然科学基金;
关键词
sumoylation; mRNA transcription; mRNA processing; RNA editing; miRNA biogenesis; cancer; RECEPTOR TRANSCRIPTIONAL ACTIVITY; DOMAIN-ASSOCIATED PROTEIN; SUMO-CONJUGATING ENZYME; CREB-BINDING PROTEIN; PML NUCLEAR-BODIES; ANDROGEN RECEPTOR; HISTONE SUMOYLATION; PROSTATE-CANCER; SYSTEMATIC IDENTIFICATION; PROTEOMIC ANALYSIS;
D O I
10.3389/fmolb.2023.1137215
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Post-translational modifications of proteins play very important roles in regulating RNA metabolism and affect many biological pathways. Here we mainly summarize the crucial functions of small ubiquitin-like modifier (SUMO) modification in RNA metabolism including transcription, splicing, tailing, stability and modification, as well as its impact on the biogenesis and function of microRNA (miRNA) in particular. This review also highlights the current knowledge about SUMOylation regulation in RNA metabolism involved in many cellular processes such as cell proliferation and apoptosis, which is closely related to tumorigenesis and cancer progression.
引用
收藏
页数:17
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