mRNA nanodelivery systems: targeting strategies and administration routes

被引：23
|
作者：
Yuan, Mujie [1 ]
Han, Zeyu [1 ]
Liang, Yan [2 ]
Sun, Yong [2 ]
He, Bin [3 ]
Chen, Wantao [4 ]
Li, Fan [1 ]
机构：
[1] Qingdao Univ, Affiliated Hosp, Dept Oral Implantol, Qingdao 266000, Peoples R China
[2] Qingdao Univ, Sch Pharm, Dept Pharmaceut, Qingdao 266073, Peoples R China
[3] Sichuan Univ, Natl Engn Res Ctr Biomat, Chengdu 610064, Peoples R China
[4] Shanghai Jiao Tong Univ, Sch Med, Shanghai Peoples Hosp 9, Dept Oral & Maxillofacial Head & Neck Oncol, Shanghai 200011, Peoples R China
来源：
BIOMATERIALS RESEARCH | 2023年 / 27卷 / 01期
基金：
美国国家科学基金会;
关键词：
mRNA; Nanodelivery systems; Targeting; Administration routes; NUCLEIC-ACID DELIVERY; LIPID NANOPARTICLES; IN-VIVO; DENDRITIC CELLS; PHYSICOCHEMICAL PROPERTIES; POLYMERIC NANOPARTICLES; BIOLOGICAL BARRIERS; DRUG-DELIVERY; PROTEIN; VACCINE;
D O I：
10.1186/s40824-023-00425-3
中图分类号：
R318 [生物医学工程];
学科分类号：
0831 ;
摘要：
With the great success of coronavirus disease (COVID-19) messenger ribonucleic acid (mRNA) vaccines, mRNA therapeutics have gained significant momentum for the prevention and treatment of various refractory diseases. To function efficiently in vivo and overcome clinical limitations, mRNA demands safe and stable vectors and a reasonable administration route, bypassing multiple biological barriers and achieving organ-specific targeted delivery of mRNA. Nanoparticle (NP)-based delivery systems representing leading vector approaches ensure the successful intracellular delivery of mRNA to the target organ. In this review, chemical modifications of mRNA and various types of advanced mRNA NPs, including lipid NPs and polymers are summarized. The importance of passive targeting, especially endogenous targeting, and active targeting in mRNA nano-delivery is emphasized, and different cellular endocytic mechanisms are discussed. Most importantly, based on the above content and the physiological structure characteristics of various organs in vivo, the design strategies of mRNA NPs targeting different organs and cells are classified and discussed. Furthermore, the influence of administration routes on targeting design is highlighted. Finally, an outlook on the remaining challenges and future development toward mRNA targeted therapies and precision medicine is provided.
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收藏
页数：48
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